HIGH-RESOLUTION IMAGING OF OCULAR MELANOMA AND RETINA

描述（申请人的描述）：高分辨率成像允许改进的成像。 了解视网膜疾病和病理条件，特别是在 恶性脉络膜黑色素瘤，年龄相关性黄斑变性， 糖尿病视网膜病变、艾滋病眼部并发症和青光眼。眼睛能 仅被认为是达到瞳孔直径的衍射受限光学系统 标准视网膜成像技术使用3 mm成像孔径， 避免外角膜的高阶像差。但如果这些 可以补偿更高阶的像差，在7 或8mm的瞳孔直径。的数值孔径 在7或8 mm瞳孔处的衍射受限的眼睛将允许可视化视网膜 这是以前眼科学无法实现的细节。实现这一 我们计划开发一种波前传感器，使我们能够测量 被测眼睛的现有像差。我们将在眼睛模型中进行测试， 动物的眼睛和人类的眼睛。波前传感器将连接到 眼底照相机和扫描激光检眼镜。第二个目标是使用 用于校正反馈回路中的像差的自适应波前补偿器 setup.我们将测试波前传感器和波前的完整系统 补偿器在眼睛模型中、在动物眼睛中和在人类眼睛中。波前 补偿器将连接到眼底照相机和扫描激光器 检眼镜第三个目的是利用数字图像处理技术进行校正 对于不能被补偿的剩余像差部分， 自适应波前补偿器由于机械的考虑。我们集团 先前已经开发了一种基于 微机械薄膜变形镜。归因于受限数目个 电极，我们的计算机系统的速度慢和机械刚度， 我们不能完全校正所有测量的像差。 我们的初步工作表明，该系统是能够允许波前 纠正一下在这项研究中，我们计划提高我们的采集速度， 波前传感器和波前补偿器 赔偿我们的初步结果表明，即使是最好的畸变， 补偿仍然受到残余波像差的影响。既然我们可以测量 并描述这些像差，我们可以开发数字逆滤波器， 根据我们在图像重建方面的经验来校正所获得的图像。

DESCRIPTION (Applicant's Description): High-resolution imaging allows improved understanding of retinal disease and pathological conditions, particularly in prognosis of malignant choroidal melanoma, age-related macular degeneration, diabetic retinopathy, ocular complications of AIDS and glaucoma. The eye can only be regarded as a diffraction-limited optical system up to a pupil diameter of 3 mm. Standard retinal imaging technology uses a 3 mm imaging aperture to avoid the higher order aberrations of the outer cornea. However, if these higher order aberrations can be compensated, diffraction-limited imaging at 7 or 8 mm pupil diameter can be achieved. The numerical aperture of the diffraction-limited eye at 7 or 8 mm pupil will allow to visualize retinal detail that was previously not achievable in ophthalmology. To achieve this goal we plan to develop a wavefront sensor that will allow us to measure the existing aberrations of the measured eye. We will test it in an eye model, in animal eyes and in human eyes. The wavefront sensor will be attached to a fundus camera and scanning laser ophthalmoscopes. The second aim is to use an adaptive wavefront compensator to correct the aberrations in a feed-back loop setup. We will test the complete system of wavefront sensor and wavefront compensator in an eye model, in animal eyes and in human eyes. The wavefront compensator will be attached to a fundus camera and scanning laser ophthalmoscopes. The third aim is to used digital image processing to correct for the portion of the residual aberrations that could not be compensated with the adaptive wavefront compensator due to mechanical considerations. Our group has previous developed a wavefront sensor and wavefront compensator based on a micromachined membrane deformable mirror. Due to the limited number of electrodes, slow speed of our computer system and the mechanical stiffness of the membrane we were not able to completely correct all measured aberrations. Our preliminary work shows that the system is capable of allowing wavefront correction. In this study we plan to improve the acquisition speed of our wavefront sensor and wavefront compensator to allow rapid wavefront compensation. Our preliminary results have shown that even the best aberration compensation still suffers from residual wave aberrations. Since we can measure and characterize these aberrations, we can develop digital inverse filter based on our experience in image reconstruction to correct the acquired images.