HD2A RASC-SUD Implementation Support Core

这项研究是NIH帮助结束长期成瘾（HEAL）计划的一部分，旨在加速科学解决国家阿片类药物公共卫生危机。NIH HEAL倡议支持整个NIH的研究，以改善阿片类药物滥用和成瘾的治疗，并制定能够为阿片类药物危机提供快速和持久解决方案的具体战略。SUD实施支持核心：项目概要/摘要尽管联邦投入大量资金开发和推广药物使用障碍（SUD）的循证药理学和行为干预措施，但药物过量死亡率仍在持续上升。由于将研究知识和循证SUD干预措施转化为公共卫生实践的挑战，试图在过量死亡问题上采取行动的努力已经停滞。在整个美国医疗保健系统中，获得基于证据的SUD干预措施的机会仍然非常有限，特别是对于历史上被边缘化的人群，如黑人/非洲裔美国人，夏威夷原住民/太平洋岛民，亚裔美国人和无保险的人。将研究成果公平地转化为实践是传播和实施科学的领域。作为HD 2A研究采用支持中心（RASC）的核心组成部分，SUD实施支持（SUD-IS）核心将为创新项目带来最好的D&I科学，以指导基于证据的，适合当地的SUD干预措施的选择，实施和维持，以减少严重打击社区的过量风险。核心领导力将统一实施科学家和SUD研究人员-通过利用尖端的D&I措施和方法，并利用我们团队对团队科学的承诺，以提高创新项目的影响力为近期目标，以改善公共健康为最终目标。SUD-IS核心在主题和操作上与RASC和其他核心协同，将通过ASSESS、ASSIST和ADVANCE的动态和迭代阶段提升创新项目。我们将首先评估SUD干预措施的证据现状，以便：a）制定循证和新兴实践的系统目录;以及B）为创新项目和基于五个关键D&I结构（例如，背景决定因素、对干预措施的证据支持、利益攸关方的参与、实施战略和实施成果，包括公平和耻辱）。然后，我们将利用在评估阶段收集的信息协助创新项目，以便：a）利用核心专业知识，通过量身定制的D&I方法增强其研究的动力; B）提供D&I实施支持计划，并使用共同决策方法来确定如何最好地提供技术援助;以及c）共同领导RASC学习协作。最后，我们将推进创新项目在可持续、公平和减少污名方面的活动：将项目与整个领域联系起来，促进对政策/融资的影响，并促进利益攸关方持续参与宣传。与RASC完全一致，我们一起朝着关闭持续和不公平的差距迈出了重要的一步，以获得经证实的药物和心理社会治疗SUD。

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction and to develop concrete strategies capable of providing rapid and durable solutions to the opioid crisis. SUD IMPLEMENTATION SUPPORT CORE: PROJECT SUMMARY/ABSTRACT Drug overdose fatalities have continued to rise despite massive federal investment in developing and disseminating evidence-based pharmacological and behavioral interventions for substance use disorders (SUDs). Attempts to move the needle on overdose deaths have stalled because of challenges translating research knowledge and evidence-based SUD interventions into public health practice. Access to evidence- based SUD interventions remains woefully limited throughout the U.S. health care system, particularly for historically marginalized populations such as Black/African-Americans, Native Hawaiians/Pacific Islanders, Asian Americans, and the uninsured. Equitable translation of research findings into practice is the domain of dissemination and implementation (D&I) science. A core component of the HD2A Research Adoption Support Center (RASC), the SUD Implementation Support (SUD-IS) Core will bring the best of D&I science to the Innovation Projects to guide the selection, implementation, and sustainment of evidence-based, locally appropriate SUD interventions to reduce overdose risk in hard hit communities. Core leadership will unify implementation scientists and SUD researchers - with the proximal goal of enhancing the impact of the Innovation Projects and the ultimate goal of improving public health - by leveraging cutting-edge D&I measures and methods, and capitalizing on our team’s commitment to team science. Thematically and operationally in tandem with the RASC and other cores, the SUD-IS Core will elevate the Innovation Projects through dynamic and iterative phases of ASSESS, ASSIST, and ADVANCE. We will first ASSESS the current state of evidence for SUD interventions in order to: a) develop a systematic catalog of evidence-based and emerging practices; and b) develop an SUD Intervention D&I Resource Guide for the Innovation Projects and any SUD intervention implementation project based on five key D&I constructs (e.g., contextual determinants, evidentiary support for the intervention, stakeholder engagement, implementation strategies, and implementation outcomes including equity and stigma). We will then ASSIST the Innovation Projects using information gathered in the ASSESS phase in order to: a) enhance motivation to enhance their studies with tailored D&I approaches that draw upon Core expertise; b) provide a D&I Implementation Support Plan and use a shared decision-making approach to determine how best to offer technical assistance; and c) co-lead the RASC Learning Collaborative. Finally, we will ADVANCE the Innovation Projects’ activities with respect to sustainment, equity, and stigma reduction: linking projects with the field at large, promoting impacts on policy/financing and facilitating ongoing stakeholder engagement towards advocacy. Perfectly aligned with the RASC, together we take a major step toward closing the persistent and inequitable gap of access to proven pharmacologic and psychosocial treatments for SUD.