Implementing contingency management in opioid treatment centers across New England: A hybrid type 3 trial
在新英格兰各地的阿片类药物治疗中心实施应急管理:一项混合 3 型试验
基本信息
- 批准号:10665470
- 负责人:
- 金额:$ 72.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAchievementAddressAdoptionBehavior TherapyBehavioralBiologicalClimateCluster randomized trialCombined Modality TherapyCompetenceComputerized Medical RecordCoupledDataData CollectionEducational workshopEffectivenessElementsEpidemicEvidence based practiceExperimental DesignsFDA approvedFeedbackFormulationFundingGoalsHybridsIncentivesKnowledgeLeadershipLearningLettersMeasurementMeasuresMediatingMethodsModelingMotivationNational Institute of Drug AbuseNew EnglandOpioidOutcomeOutcome StudyPatient Outcomes AssessmentsPatient Self-ReportPatient-Focused OutcomesPatientsPerformancePharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePilot ProjectsPlacebosProceduresPsychological reinforcementPublic HealthQuality of CareRandomizedResearchRewardsSamplingSiteTechnology TransferTestingTimeTrainingUnited StatesUnited States National Institutes of HealthUnited States Substance Abuse and Mental Health Services AdministrationUrineWorkaddictionbaseblindcommunity settingcontingency managementdesigneffectiveness testingevidence baseexperimental studyfollow-upimplementation barriersimplementation effortsimplementation evaluationimplementation measuresimplementation outcomesimplementation strategyimprovedimproved outcomeinnovationnovelnovel strategiesopioid overdoseopioid use disorderoverdose deathpilot trialpractice settingpublic health emergencypublic health relevanceresponsetreatment centertrial comparinguptake
项目摘要
Project Description
Overdoses and deaths due to opioid use disorders (OUDs) have been declared a public health emergency in
the United States, bringing to light an urgent need for highly effective OUD treatments. There are currently five
FDA-approved medication formulations, which relative to placebo have demonstrated effectiveness in helping
patients attain abstinence from opioids. Nonetheless, patients' opioid abstinence rates are sub-optimal: even
when treated with the newest extended-release formulations only about 40% of patients maintain abstinence
during the first 6-months of treatment. Contingency management (CM; i.e., motivational incentives for
achieving pre-defined treatment goals) is one of the only behavioral interventions shown to improve patient
abstinence from opioids when combined with FDA-approved pharmacotherapy. Unfortunately, however,
uptake of CM in OUD treatment centers remains low. In response to the urgent need for evidence-based
behavioral OUD treatments, we propose a large-scale type 3 hybrid trial comparing two comprehensive
strategies to promote CM implementation as an adjunct to pharmacotherapy within OUD centers. The control
condition is the staff training strategy used by the SAMHSA-funded network of Addiction Technology Transfer
Centers (ATTC; i.e., didactic workshop + performance feedback + staff coaching). The experimental condition
is the ATTC strategy enhanced by external leadership coaching (ELC; i.e., leadership coaching focused on
sustainment planning) and pay-for-performance (P4P; i.e., monetary bonuses for achieving pre-defined
implementation goals), which we refer to hereafter as E-ATTC. Elements of E-ATTC were informed by our
team's prior NIH-funded work evaluating organization-level implementation strategies. Using a cluster
randomized design, 30 OUD treatment centers across New England will be randomized to one of the two
implementation conditions (ATTC vs. E-ATTC) over the 5 year project. At each OUD treatment center, data will
be collected at multiple intervals from two CM staff (n=60), two organizational leaders (n=60), and 25 newly
admitted patients (n=750). Additionally, 25 patient charts per center (n=750) will be randomly selected for
review to examine sustainment. Data collection will use rigorous, replicable procedures including electronic
medical record review, ratings of audio recordings by staff blind to condition, well-validated measures, and
biological verification of abstinence. Specific Aims of the study are to experimentally compare the effect of the
two conditions on implementation outcomes (Primary Aim) and on patient outcomes (Secondary Aim). An
Exploratory Aim is to test whether two organization-level variables (i.e., implementation climate, leadership
engagement) partially mediate the relationship between implementation condition and the key study outcomes.
Achievement of the Study Aims will address critical public health needs by (a) informing how evidence-based
practice is implemented in OUD treatment centers, (b) improving the outcomes of OUD patients on
pharmacotherapy, and (c) advancing knowledge about why and how implementation strategies work.
项目描述
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sustainment of Contingency Management within Opioid Treatment Programs: COVID-Related Barriers and Innovative Workflow Adaptations.
阿片类药物治疗计划中应急管理的维持:与新冠病毒相关的障碍和创新工作流程调整。
- DOI:10.1016/j.dadr.2021.100003
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Becker,SaraJ;Bowen,CaitlynA;Reed,EllainaN;Lang,Sharon;Correia,Nicholas;Yermash,Julia;Yap,KimberlyR;Rash,CarlaJ;Garner,BryanR
- 通讯作者:Garner,BryanR
Virtual Training Is More Cost-Effective Than In-Person Training for Preparing Staff to Implement Contingency Management.
在培训员工实施应急管理方面,虚拟培训比面对面培训更具成本效益。
- DOI:10.1007/s41347-022-00283-1
- 发表时间:2022-10-12
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Early COVID-Related pandemic impacts and subsequent opioid outcomes among persons receiving medication for opioid use disorder: a secondary data analysis of a Type-3 hybrid trial.
- DOI:10.1186/s13722-023-00409-7
- 发表时间:2023-09-13
- 期刊:
- 影响因子:3.7
- 作者:Janssen, Tim;Garner, Bryan R.;Yermash, Julia;Yap, Kimberly R.;Becker, Sara J.
- 通讯作者:Becker, Sara J.
Impacts of the COVID-19 pandemic on healthcare access among patients receiving medication for opioid use disorder.
- DOI:10.1016/j.drugalcdep.2021.108617
- 发表时间:2021-04-01
- 期刊:
- 影响因子:4.2
- 作者:Jacka BP;Janssen T;Garner BR;Yermash J;Yap KR;Ball EL;Hartzler B;Becker SJ
- 通讯作者:Becker SJ
Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics): A cluster-randomized type 3 hybrid effectiveness-implementation trial.
- DOI:10.1186/s13722-021-00268-0
- 发表时间:2021-10-12
- 期刊:
- 影响因子:3.7
- 作者:Becker SJ;Murphy CM;Hartzler B;Rash CJ;Janssen T;Roosa M;Madden LM;Garner BR
- 通讯作者:Garner BR
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Sara J. Becker其他文献
Evaluation of sex disparities in opioid use among ED patients with sickle cell disease, 2006-2015.
2006-2015 年镰状细胞病 ED 患者阿片类药物使用性别差异的评估。
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:3.6
- 作者:
T. Wilson;Shih;Sara J. Becker;J. Schuur;F. Beaudoin - 通讯作者:
F. Beaudoin
Randomized Clinical Trials in Behavioral Medicine
行为医学随机临床试验
- DOI:
10.1007/978-0-387-93826-4_5 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
K. Freedland;Sara J. Becker;J. Blumenthal - 通讯作者:
J. Blumenthal
Interventions for Substance Use Disorders in Adolescents: A Systematic Review
青少年药物使用障碍的干预措施:系统评价
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
D. Steele;Sara J. Becker;Kristin J. Danko;E. Balk;I. Saldanha;G. Adam;S. Bagley;C. Friedman;A. Spirito;Kelli Scott;E. Ntzani;Imani Saeed;Bryant T. Smith;J. Popp;T. Trikalinos - 通讯作者:
T. Trikalinos
Proceedings of the 13th annual conference of INEBRIA
- DOI:
10.1186/s13722-016-0062-9 - 发表时间:
2016-09-01 - 期刊:
- 影响因子:3.200
- 作者:
Rod Watson;James Morris;John Isitt;Pablo Barrio;Lluisa Ortega;Antoni Gual;Kenneth Conner;Tracy Stecker;Stephen Maisto;Sophie Paroz;Caroline Graap;Véronique S Grazioli;Jean-Bernard Daeppen;Susan E Collins;Nicolas Bertholet;Jennifer McNeely;Vlad Kushnir;John A. Cunningham;Iain K Crombie;Kathryn B Cunningham;Linda Irvine;Brian Williams;Falko F Sniehotta;John Norrie;Ambrose Melson;Claire Jones;Andrew Briggs;Peter Rice;Marcus Achison;Andrew McKenzie;Elena Dimova;Peter W Slane;Véronique S. Grazioli;Susan E. Collins;Sophie Paroz;Caroline Graap;Jean-Bernard Daeppen;Stéphanie Baggio;Marc Dupuis;Joseph Studer;Gerhard Gmel;Molly Magill;Véronique S. Grazioli;Robert J. Tait;Lucinda Teoh;Erin Kelty;Elizabeth Geelhoed;David Mountain;Gary K. Hulse;Elina Renko;Shannon G. Mitchell;David Lounsbury;Zhi Li;Robert P. Schwartz;Jan Gryczynski;Arethusa S. Kirk;Marla Oros;Colleen Hosler;Kristi Dusek;Barry S. Brown;Deborah S. Finnell;Aisha Holloway;Li-Tzy Wu;Geetha Subramaniam;Gaurav Sharma;Sara Wallhed Finn;Sven Andreasson;Robert D. Dvorak;Matthew P. Kramer;Brittany L. Stevenson;Emily M. Sargent;Tess M. Kilwein;Sion K. Harris;Lon Sherritt;Sarah Copelas;John R. Knight;Noreen D Mdege;Jim McCambridge;Gallus Bischof;Anja Bischof;Jennis Freyer-Adam;Hans-Juergen Rumpf;Niamh Fitzgerald;Lisa Schölin;Paul Toner;Jan R. Böhnke;Laura J. Veach;Olivia Currin;Leigh Z. Dongre;Preston R. Miller;Elizabeth White;Emily C. Williams;Gwen T. Lapham;Jennifer J. Bobb;Anna D. Rubinsky;Sheryl L. Catz;Susan Shortreed;Kara M. Bensley;Katharine A. Bradley;Joanna Milward;Paolo Deluca;Zarnie Khadjesari;Rod Watson;Stephanie Fincham-Campbell;Colin Drummond;Kathryn Angus;Linda Bauld;Sophie Baumann;Katja Haberecht;Inga Schnuerer;Christian Meyer;Hans-Jürgen Rumpf;Ulrich John;Beate Gaertner;Marion Barrault-Couchouron;Marion Béracochéa;Vincent Allafort;Valérie Barthélémy;Hervé Bonnefoi;Emmanuel Bussières;Véronique Garguil;Marc Auriacombe;Marianne Saint-Jacques;Michel Dorval;Katia M’Bailara;Lidia Segura-Garcia;Nuria Ibañez-Martinez;Juan Manuel Mendive-Arbeloa;Manel Anoro-Perminger;Pako Diaz-Gallego;Mª Angeles Piñar-Mateos;Joan Colom-Farran;Marianthi Deligianni;Bertrand Yersin;Angeline Adam;Constance Weisner;Felicia Chi;Wendy Lu;Stacy Sterling;Kevin L. Kraemer;Kathleen A. McGinnis;David A. Fiellin;Melissa Skanderson;Adam J. Gordon;Jonathan Robbins;Susan Zickmund;P. Todd Korthuis;E. Jennifer Edelman;Nathan B. Hansen;Christopher J. Cutter;James Dziura;Lynn E. Fiellin;Patrick G. O’Connor;Stephen A. Maisto;Roger Bedimo;Cynthia Gilbert;Vincent C. Marconi;David Rimland;Maria Rodriguez-Barradas;Michael Simberkoff;Amy C. Justice;Kendall J. Bryant;Anne H Berman;Gillian W Shorter;Jeremy W Bray;Carolina Barbosa;Magnus Johansson;Reid Hester;William Campbell;Maria Lucia O. Souza Formigoni;André Luzi Monezi Andrade;Laisa Marcorela Andreoli Sartes;Christopher Sundström;Niels Eék;Martin Kraepelien;Viktor Kaldo;Claudia Fahlke;Lynn Hernandez;Sara J. Becker;Richard N. Jones;Hannah R. Graves;Anthony Spirito;Silke Diestelkamp;Lutz Wartberg;Nicolas Arnaud;Rainer Thomasius;Jacques Gaume;Véronique Grazioli;Cristiana Fortini;Zelra Malan;Bob Mash;Katherine Everett-Murphy;Véronique S. Grazioli;Joseph Studer;M. Mohler-Kuo;Nicolas Bertholet;Gerhard Gmel;Lawrence Doi;Helen Cheyne;Ruth Jepson;Vanesa Luna;Leticia Echeverria;Silvia Morales;Teresa Barroso;Ângela Abreu;Cosma Aguiar;Duncan Stewart;Angela Abreu;Riany M. Brites;Rafael Jomar;Gerson Marinho;Pedro Parreira;J. Paul Seale;J. Aaron Johnson;Dena Henry;Sharon Chalmers;Freida Payne;Linda Tuck;Akula Morris;Cátia Gonçalves;Bettina Besser;Cristina Casajuana;Hugo López-Pelayo;María Mercedes Balcells;Lídia Teixidó;Laia Miquel;Joan Colom;Kimberly A. Hepner;Katherine. J. Hoggatt;Andy Bogart;Susan. M. Paddock;Sarah L Hardoon;Irene Petersen;Fiona L Hamilton;Irwin Nazareth;Ian R. White;Louise Marston;Paul Wallace;Christine Godfrey;Elizabeth Murray;Hana Sovinová;Ladislav Csémy - 通讯作者:
Ladislav Csémy
“Sounds like CSI:” How consumers of adolescent substance use disorder treatment perceive the term “evidence-based practice”
“听起来像犯罪现场调查:”青少年物质使用障碍的消费者如何看待“循证实践”一词的治疗
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:3.7
- 作者:
Sara J. Becker;Miriam M Midoun;A. Spirito - 通讯作者:
A. Spirito
Sara J. Becker的其他文献
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{{ truncateString('Sara J. Becker', 18)}}的其他基金
HD2A RASC-SUD Implementation Support Core
HD2A RASC-SUD 实施支持核心
- 批准号:
10596437 - 财政年份:2022
- 资助金额:
$ 72.23万 - 项目类别:
HD2A RASC-SUD Implementation Support Core
HD2A RASC-SUD 实施支持核心
- 批准号:
10708983 - 财政年份:2022
- 资助金额:
$ 72.23万 - 项目类别:
C-DIAS RP 2: Implementing contingency management for stimulant use in specialty addiction treatment organizations
C-DIAS RP 2:在专业成瘾治疗组织中实施兴奋剂使用应急管理
- 批准号:
10668488 - 财政年份:2022
- 资助金额:
$ 72.23万 - 项目类别:
C-DIAS RP 2: Implementing contingency management for stimulant use in specialty addiction treatment organizations
C-DIAS RP 2:在专业成瘾治疗组织中实施兴奋剂使用应急管理
- 批准号:
10493960 - 财政年份:2022
- 资助金额:
$ 72.23万 - 项目类别:
Improving Outcomes of Adolescents in Residential Substance use Treatment via a Technology-Assisted Parenting Intervention
通过技术辅助育儿干预改善青少年住宅药物滥用治疗的结果
- 批准号:
10666175 - 财政年份:2021
- 资助金额:
$ 72.23万 - 项目类别:
Neighborhood perceptions and response to a technology-assisted parenting intervention for youth substance use
社区对针对青少年药物滥用的技术辅助育儿干预的看法和反应
- 批准号:
10836689 - 财政年份:2021
- 资助金额:
$ 72.23万 - 项目类别:
Implementing contingency management in opioid treatment centers across New England: A hybrid type 3 trial
在新英格兰各地的阿片类药物治疗中心实施应急管理:一项混合 3 型试验
- 批准号:
10400426 - 财政年份:2018
- 资助金额:
$ 72.23万 - 项目类别:
Implementing contingency management in opioid treatment centers across New England: A hybrid type 3 trial
在新英格兰各地的阿片类药物治疗中心实施应急管理:一项混合 3 型试验
- 批准号:
10215461 - 财政年份:2018
- 资助金额:
$ 72.23万 - 项目类别:
Adolescents with Substance Use Disorders Transitioning from Residential Treatment to the Community: Improving Outcomes via a Computer Assisted Parenting Program
患有药物滥用障碍的青少年从住院治疗过渡到社区:通过计算机辅助育儿计划改善治疗结果
- 批准号:
9034960 - 财政年份:2016
- 资助金额:
$ 72.23万 - 项目类别:
Adolescents with Substance Use Disorders Transitioning from Residential Treatment to the Community: Improving Outcomes via a Computer Assisted Parenting Program
患有药物滥用障碍的青少年从住院治疗过渡到社区:通过计算机辅助育儿计划改善治疗结果
- 批准号:
9263967 - 财政年份:2016
- 资助金额:
$ 72.23万 - 项目类别:
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