Implementing contingency management in opioid treatment centers across New England: A hybrid type 3 trial

在新英格兰各地的阿片类药物治疗中心实施应急管理：一项混合 3 型试验

• 批准号: 10665470
• 负责人: Sara J. Becker
• 金额: $ 72.23万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10665470
• 关键词: Abstinence; Achievement; Address; Adoption; Behavior Therapy; Behavioral; Biological; Climate; Cluster randomized trial; Combined Modality Therapy; Competence; Computerized Medical Record; Coupled; Data; Data Collection; Educational workshop; Effectiveness; Elements; Epidemic; Evidence based practice; Experimental Designs; FDA approved; Feedback; Formulation; Funding; Goals; Hybrids; Incentives; Knowledge; Leadership; Learning; Letters; Measurement; Measures; Mediating; Methods; Modeling; Motivation; National Institute of Drug Abuse; New England; Opioid; Outcome; Outcome Study; Patient Outcomes Assessments; Patient Self-Report; Patient-Focused Outcomes; Patients; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Phase; Pilot Projects; Placebos; Procedures; Psychological reinforcement; Public Health; Quality of Care; Randomized; Research; Rewards; Sampling; Site; Technology Transfer; Testing; Time; Training; United States; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Urine; Work; addiction; base; blind; community setting; contingency management; design; effectiveness testing; evidence base; experimental study; follow-up; implementation barriers; implementation efforts; implementation evaluation; implementation measures; implementation outcomes; implementation strategy; improved; improved outcome; innovation; novel; novel strategies; opioid overdose; opioid use disorder; overdose death; pilot trial; practice setting; public health emergency; public health relevance; response; treatment center; trial comparing; uptake

Project Description Overdoses and deaths due to opioid use disorders (OUDs) have been declared a public health emergency in the United States, bringing to light an urgent need for highly effective OUD treatments. There are currently five FDA-approved medication formulations, which relative to placebo have demonstrated effectiveness in helping patients attain abstinence from opioids. Nonetheless, patients' opioid abstinence rates are sub-optimal: even when treated with the newest extended-release formulations only about 40% of patients maintain abstinence during the first 6-months of treatment. Contingency management (CM; i.e., motivational incentives for achieving pre-defined treatment goals) is one of the only behavioral interventions shown to improve patient abstinence from opioids when combined with FDA-approved pharmacotherapy. Unfortunately, however, uptake of CM in OUD treatment centers remains low. In response to the urgent need for evidence-based behavioral OUD treatments, we propose a large-scale type 3 hybrid trial comparing two comprehensive strategies to promote CM implementation as an adjunct to pharmacotherapy within OUD centers. The control condition is the staff training strategy used by the SAMHSA-funded network of Addiction Technology Transfer Centers (ATTC; i.e., didactic workshop + performance feedback + staff coaching). The experimental condition is the ATTC strategy enhanced by external leadership coaching (ELC; i.e., leadership coaching focused on sustainment planning) and pay-for-performance (P4P; i.e., monetary bonuses for achieving pre-defined implementation goals), which we refer to hereafter as E-ATTC. Elements of E-ATTC were informed by our team's prior NIH-funded work evaluating organization-level implementation strategies. Using a cluster randomized design, 30 OUD treatment centers across New England will be randomized to one of the two implementation conditions (ATTC vs. E-ATTC) over the 5 year project. At each OUD treatment center, data will be collected at multiple intervals from two CM staff (n=60), two organizational leaders (n=60), and 25 newly admitted patients (n=750). Additionally, 25 patient charts per center (n=750) will be randomly selected for review to examine sustainment. Data collection will use rigorous, replicable procedures including electronic medical record review, ratings of audio recordings by staff blind to condition, well-validated measures, and biological verification of abstinence. Specific Aims of the study are to experimentally compare the effect of the two conditions on implementation outcomes (Primary Aim) and on patient outcomes (Secondary Aim). An Exploratory Aim is to test whether two organization-level variables (i.e., implementation climate, leadership engagement) partially mediate the relationship between implementation condition and the key study outcomes. Achievement of the Study Aims will address critical public health needs by (a) informing how evidence-based practice is implemented in OUD treatment centers, (b) improving the outcomes of OUD patients on pharmacotherapy, and (c) advancing knowledge about why and how implementation strategies work.

项目描述

项目成果

Sustainment of Contingency Management within Opioid Treatment Programs: COVID-Related Barriers and Innovative Workflow Adaptations.

阿片类药物治疗计划中应急管理的维持：与新冠病毒相关的障碍和创新工作流程调整。

• DOI: 10.1016/j.dadr.2021.100003
• 发表时间: 2021
• 期刊: Drug and alcohol dependence reports
• 作者: Becker,SaraJ;Bowen,CaitlynA;Reed,EllainaN;Lang,Sharon;Correia,Nicholas;Yermash,Julia;Yap,KimberlyR;Rash,CarlaJ;Garner,BryanR
• 通讯作者: Garner,BryanR

Virtual Training Is More Cost-Effective Than In-Person Training for Preparing Staff to Implement Contingency Management.

在培训员工实施应急管理方面，虚拟培训比面对面培训更具成本效益。

• DOI: 10.1007/s41347-022-00283-1
• 发表时间: 2022-10-12
• 期刊: Journal of technology in behavioral science

Early COVID-Related pandemic impacts and subsequent opioid outcomes among persons receiving medication for opioid use disorder: a secondary data analysis of a Type-3 hybrid trial.

• DOI: 10.1186/s13722-023-00409-7
• 发表时间: 2023-09-13
• 期刊: ADDICTION SCIENCE & CLINICAL PRACTICE
• 影响因子: 3.7
• 作者: Janssen, Tim;Garner, Bryan R.;Yermash, Julia;Yap, Kimberly R.;Becker, Sara J.
• 通讯作者: Becker, Sara J.

Impacts of the COVID-19 pandemic on healthcare access among patients receiving medication for opioid use disorder.

• DOI: 10.1016/j.drugalcdep.2021.108617
• 发表时间: 2021-04-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Jacka BP;Janssen T;Garner BR;Yermash J;Yap KR;Ball EL;Hartzler B;Becker SJ
• 通讯作者: Becker SJ

Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics): A cluster-randomized type 3 hybrid effectiveness-implementation trial.

• DOI: 10.1186/s13722-021-00268-0
• 发表时间: 2021-10-12
• 期刊: Addiction science & clinical practice
• 影响因子: 3.7
• 作者: Becker SJ;Murphy CM;Hartzler B;Rash CJ;Janssen T;Roosa M;Madden LM;Garner BR
• 通讯作者: Garner BR