Interdisciplinary Training Program in Muscle Biology

该计划为博士前学生和博士后提供肌肉生物学的跨学科培训 伙计们该计划强调骨骼，心脏和心脏的功能，结构和分子特性。 平滑肌，以及这些特性如何在各种疾病状态下受到损害。我们的18名教师 来自2个基础科学部门（生物化学与分子生物学和生理学）和5个临床 各部门（内科、骨科、病理学、物理治疗和康复以及外科） 马里兰州大学医学院。附属教师也来自机械系 工程和数学与统计在我们的姐妹校区，马里兰州巴尔的摩县的大学，和 来自摩根州立大学。学员来自所有参与部门和我们的 跨部门博士课程。表明我们教师背景的多样性，提供的培训是 从肌肉发育的分子决定因素到细胞生物学方面， 肌肉细胞骨架，膜和基质的生物物理分析，个体肌肉细胞功能和 在所有这些水平上对整个肌肉的生物力学评估对肌肉疾病的影响 调查我们的教师是国内和国际公认的钙控制肌肉的领域 功能和膜系统，肌肉细胞骨架和细胞外基质，肌肉发育，生长 和可塑性，以及肌肉疾病，损伤和衰老。我们的学生将接受培训，在这些和在一个 各种相关领域，重点是使用最先进的补充技术， 每一个问题都在检查中。我们培训的主要教学方面是两个一学期的跨学科 肌肉生物学课程，这是由程序教师团队授课，并已深受过去 培训生，和一个研讨会系列侧重于肌肉相关的技术，技术和模型系统。 计划活动包括每年一次的校园迷你务虚会，其中包括学员海报和口头 演讲和著名的肌肉研究人员作为程序访问者和主旨发言人，半年一次的韦德 为所有受训人员举办纪念讲座和午餐会，以及职业发展培训， 补助金和手稿的写作，严谨性和可重复性的原则，以及负责任的研究行为。 我们将继续在我们目前的水平5博士前和5博士后培训生在整个更新期间。 进入博士前培训生将被要求有一个强大的背景，在生物科学和赞扬 推荐信。新入职的博士后培训生将完成一篇扎实的博士论文， 强有力的推荐信。从这个计划的学员将准备带来广泛的方法 致力于回答肌肉生物学的基本问题和肌肉疾病的原因， 他们可能的治疗和最终治愈。因此，该计划服务于国家需要准备高度 在肌肉生物学和疾病领域接受过多学科培训的合格研究人员。

This program provides interdisciplinary training in muscle biology for predoctoral students and postdoctoral fellows. The program emphasizes the functional, structural and molecular properties of skeletal, cardiac and smooth muscle, and how these properties are compromised in various disease states. Our 18 faculty members come from 2 basic science departments (Biochemistry & Molecular Biology and Physiology) and 5 clinical departments (Medicine, Orthopedics, Pathology, Physical Therapy & Rehabilitation, and Surgery) at the University of Maryland School of Medicine. Affiliate faculty also come from the Departments of Mechanical Engineering and Mathematics & Statistics at our sister campus, University of Maryland Baltimore County, and from Morgan State University. Trainees are drawn from all of the participating departments and from our interdepartmental PhD Programs. Indicative of the diversity of our faculty backgrounds, the training offered is multifaceted ranging from the molecular determinants of muscle development through the cell biological aspects of muscle cytoskeleton, membranes and matrix, to the biophysical analysis of individual muscle cell function and the biomechanical evaluation of whole muscles to the effects of muscle disease at all these levels of investigation. Our faculty is nationally and internationally recognized in the areas of Ca2+ control of muscle function and membrane systems, muscle cytoskeleton and extracellular matrix, muscle development, growth and plasticity, as well as muscle disease, injury and aging. Our students will receive training in these and in a variety of related areas, with emphasis on the use of complementary state-of-the-art technologies to address each question under examination. The major didactic aspect of our training is two one-semester interdisciplinary courses on muscle biology, which are team-taught by the program faculty and have been well received by past trainees, and a seminar series focusing on muscle related techniques, technologies and model systems. Program activities comprise an annual on campus Mini-Retreat which includes trainee poster and oral presentations and a renowned muscle researcher as Program visitor and Keynote Speaker, a semi-annual Wade Memorial lectureship and lunch meetings for all trainees, as well as training in professional career development, grant and manuscript writing, the principles of rigor and reproducibility, and the responsible conduct of research. We will continue at our present level of 5 predoctoral and 5 postdoctoral trainees throughout the renewal period. Entering predoctoral trainees will be required to have a strong background in biological sciences and praising recommendation letters. Incoming postdoctoral trainees will have completed a solid PhD thesis, and also have strong recommendation letters. Trainees from this program will be prepared to bring a wide range of approaches to bear on answering fundamental questions in muscle biology and on the causes of muscle diseases as well as their possible treatment and ultimately cure. This program therefore serves a national need for preparing highly competent investigators with multi-disciplinary training in the area of muscle biology and disease.