HIV Prevention Among Adolescent Women

描述(由申请人提供)：这项第二阶段SBIR将开发和测试一种基于理论、与文化相关和适合年龄的干预措施，用于在11至14岁的不同种族的早期青春期女性中降低艾滋病毒风险。根据理论和经验文献以及第一阶段的过程和结果数据，第二阶段将起草预防内容。经过一个社区专业人员小组的审查和对48名不同族裔女孩的抽样，将对干预措施进行修订和规划，以便提供光盘。CD-ROM介导性干预的有效性将在一项分组随机试验中进行检验。女孩将通过大纽约市的青年服务机构招募。在随机分配了实验和对照研究的地点后，980名女孩将完成测试前结果测量组件。实验手臂青年将在每周六次的现场会议上与该软件进行互动。两个研究组的青少年都将完成后测和六个月的随访。结果分析将确定与不干预相比，电脑干预在减少女孩艾滋病毒危险行为和假设影响这些行为的变量方面的有效性。如果光盘干预被证明是有效的，它将通过直接营销努力和通过与面向青年的健康促进和疾病预防方案的分销商签订许可协议来传播。

DESCRIPTION (provided by applicant): This Phase II SBIR will develop and test a theory-based, culturally relevant, and age-appropriate intervention for HIV risk reduction among ethnic-racially diverse early adolescent females aged 11 through 14 years. Drawing from the theoretical and empirical literature and Phase I process and outcome data, Phase II will draft prevention content. Following review by a panel of community-based professionals and sample of 48 ethnic-racially diverse girls, the intervention will be revised and programmed for CD-ROM delivery. The efficacy of the CD-ROM-mediated intervention will be examined in a group-randomized trial. Girls will be recruited through youth services agencies in greater New York City. Following random assignment of sites to experimental and control study arms, 980 girls will complete pretest outcome measurement batteries. Experimental arm youths will interact with the software in six weekly on-site sessions. Youths in both study arms will complete posttest and six-month follow-up batteries. Outcome analyses will determine the efficacy of the computer-mediated intervention, relative to no intervention, in reducing girls' HIV risk behaviors and variables hypothesized to influence these behaviors. Should the CD-ROM intervention prove effective, it will be disseminated through direct marketing efforts and through licensing agreements with distributors of youth-oriented health promotion and disease prevention programs.