Mechanisms responsible for neurogenic hypertension: Role of a novel interaction between amygdala-hypothalamic GABA pathways and the microRNA regulation of renin

我们发现，由于大脑中控制情绪和对压力的反应的小区域中有一个错误的分子，导致患有高血压的老鼠神经系统过度活跃。高度的神经活动影响肾脏中的一种可能导致高血压的激素。该提案将确定大脑中负责放大压力反应导致高血压的机制和神经化学物质，并测试一种治疗高血压的新疗法。

We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blood pressure.