Research Training in Pharmacological Sciences

描述：（由申请人提供）我们申请续期“药物科学研究训练”（RTPS博士前训练资助）。RTPS专为希望扩展分子和细胞生物学知识的学生而设计，包括现代药理学和分子成像原理，以及这些学科在细胞和组织水平上的应用。RTPS增加了化学、细胞和组织药理学以及分子成像的正式教学，并强调它们在细胞和整个动物环境中的应用。RTPS教师在细胞/分子生物学，生物化学，药理学，基因组学和分子成像方面具有专业知识。微型PET成像程序和PET报告基因技术的发展现在允许将分子和细胞药理学应用于活体动物，其基因组可以通过实验操作，以补充现有的分子和光显微镜技术。RTPS提供了从分子到小鼠到人的分子和细胞药理学研究的垂直整合，结合了从分子结构到分子医学的概念和应用。本申请拟将培训师资从本期的24人增加至36人，其中教授10人，副教授12人，助理教授14人，来自7个系。大多数（22名）导师在分子和医学药理学部门（DMMP）担任主要或联合职务。DMMP的优势来自两个因素：(1)DMMP强调现代药理学和成像技术以及细胞生物学，药理学和分子成像在DMMP中的接口；(2)在过去的五年里，DMMP招募了10名新的教师，他们的研究兴趣是RTPS项目的核心。大量的初级教师导师反映了机构对招聘具有反映RTPS目标的研究兴趣的教师的承诺。学生在研究生院一年后被选中参加RTPS，并从个人学位授予项目、加州大学洛杉矶分校ACCESS研究生入学项目、MSTP项目和加州大学洛杉矶分校STAR项目中抽取。RTPS于1998年开始，当时委任了两名学生。由于教师和学生对这一研究领域的兴趣不断增加，我们每年申请4个实习名额。DMMP和Crump分子成像研究所的资源将向所有RTPS学生开放，无论他们在哪个部门获得博士学位。

DESCRIPTION: (provided by applicant) We seek renewal of the "Research Training in Pharmaceutical Sciences" (RTPS Predoctoral Training Grant). RTPS is designed for students who want to extend their knowledge of molecular and cell biology to include principles of modern pharmacology and molecular imaging, and the application of these disciplines at cellular and organismal levels. RTPS adds formal instruction in chemical, cellular and organismal pharmacology and in molecular imaging, and emphasizes their applications in both cellular and whole animal contexts. RTPS faculty have expertise in cell/molecular biology, biochemistry, pharmacology, genomics and molecular imaging. Development of microPET imaging procedures and PET reporter gene technologies now permit application of molecular and cellular pharmacology to living animals, whose genomes can be experimentally manipulated, to complement existing molecular and light microscopic techniques. RTPS provides vertical integration of research in molecular and cellular pharmacology from molecule to mouse to man, combining concepts and applications from molecular structure through molecular medicine. Proposed training faculty increase from 24 in the current period to 36 in this application, include 10 Professors, 12 Associate Professors and 14 Assistant Professors, and come from seven departments. A majority, 22, of the mentors have primary or joint appointments in the Department of Molecular and Medical Pharmacology (DMMP). DMMP dominance results from two factors: (1) DMMP emphasis on modern pharmacologic and imaging techniques and the interface of cell biology, pharmacology and molecular imaging in DMMP and (2) recruitment of 10 new faculty, with research interests at the heart of the RTPS program, into DMMP in the last five years. The large number of junior faculty mentors reflects an institutional commitment to recruitment of faculty with research interests that reflect RTPS goals. Students are selected for RTPS after their first year in graduate school, and are drawn from a pool that comes from individual degree granting programs, the UCLA ACCESS graduate admissions program, the MSTP program and the UCLA STAR program. RTPS began in 1998, with the appointment of two students. Because of an increase in interest in this area of research, both by faculty and by students, we are requesting four trainee slots per year. Resources of the DMMP and the Crump Institute for Molecular Imaging will be available to all RTPS students, regardless of the department in which they receive their Ph.D.