Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's Disease

修订后的标题： 老年、MCI和阿尔茨海默病认知的非药物干预研究培训 修订后的项目摘要/摘要 这份竞争性续签申请要求继续在佛罗里达大学(UF)进行为期15年的博士前培训计划。为六(6)名博士前实习生申请资金。该计划侧重于认知老化(CA)、轻度认知障碍(MCI)和阿尔茨海默病(AD)的非药物干预方面的研究培训，主要有三个重点：(A)行为干预(例如，认知训练、锻炼、正念)；(B)多成分补偿干预；以及(C)针对患有或不伴有MCI和AD相关认知障碍的老年人的神经调节/刺激干预。我们有三个级别的导师：导师是具有博士前培训记录的终身资深科学家。高级顾问是领域负责人(通常是中心主任和内科科学家)，他们通常不直接监督预科医生，但提供基础设施(拨款、中心资源、数据集)，并将在指导委员会任职。实习导师(M-I-T)是有研究项目的非终身初级博士；他们将接受导师培训(例如，UF导师学院)，并将与一名资深导师一起作为学员的联合导师，预计将增强未来导师渠道的多样性。该提案所代表的学科包括应用生理学和运动学、生物医学工程学、通信科学、老年病学、神经科学/神经病学、护理学、职业治疗学、心理学、公共卫生和社会流行病学。核心计划组成部分包括：(1)将每个学生分配到一个经常召集的多学科指导小组；(2)在研究、教育和服务领域形成并密切跟踪个人发展目标；(3)定期培训主任会议，以考虑对人类研究参与者的保护、认知干预方面的理论/方法/过去的发现、严谨性和再现性以及专业发展；(4)在干预措施中需要补充课程和其他教学内容，用于CA、MCI和AD、统计/方法学、负责任的研究进行，以及严谨和可再生性。优先考虑已完成博士资格考试的学生，从而有选择地将资源投资于已完成主要项目里程碑的承诺、有成效的学生。该计划的拟议变化包括：(A)利用UF增强的能力，更加专注于将与CA、MCI和AD一起使用的干预措施；(B)增加受训人员参与协作团队科学的机制；以及(C)引入培训中导师的角色，以创建未来导师的多样化渠道。迄今取得的进展：在37名受训人员中，27人(73%)是妇女，11人(30%)是代表不足的种族/族裔少数群体成员。十二(12)名学员仍在接受培训(学生、实习生、博士后)。25名学员接受了后培训，其中22名(88%)在研究密集型或与研究相关的职位，包括：16名(%)副教授/助理教授、3名(12%)研究科学家和2名(8%)行政管理人员；17名(68%)研究一、2名研究二(8%)和3(12%)退伍军人学院的3名(12%)。

Revised Title: Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer’s Disease Revised Project Summary/Abstract This competitive renewal application requests continuation of a 15-year predoctoral training program at the University of Florida (UF). Funds are requested for six (6) predoctoral trainees. The program focuses on research training in non-pharmacological interventions for cognitive aging (CA), mild cognitive impairment (MCI) and Alzheimer’s disease (AD) with three substantive emphases: (a) behavioral interventions (e.g., cognitive training, exercise, mindfulness); (b) multi-component compensatory interventions; and (c) neuromodulation/stimulation interventions for older adults with and without MCI- and AD-related cognitive impairment. We have three levels of preceptors: Mentors are tenured senior scientists with predoctoral training track records. Senior advisors are field leaders (often center directors, and physician-scientists) who often do not directly supervise predocs, but provide infrastructure (grants, center resources, data sets) and will serve on mentoring committees. Mentors-in-training (M-i-T) are untenured junior PhDs with research programs; they will receive mentoring training (e.g., UF Mentoring Academy) and will be coupled with a senior mentor as co-mentors for trainees, and are expected to enhance the diversity of the pipeline of future mentors. Disciplines represented in this proposal include applied physiology and kinesiology, biomedical engineering, communication sciences, geriatrics, neuroscience/neurology, nursing, occupational therapy, psychology, public health, and social epidemiology. Core program components include (1) assignment of each student to a frequently convened multi-disciplinary mentoring team (2) formation and close tracking of individual developmental goals in the areas of research, education, and service; (3) regular training director meetings to consider protection of human research participants, theory/method/past findings in cognitive interventions, rigor and reproducibility, and professional development; (4) required supplemental coursework and other didactics in interventions to be used with CA, MCI and AD, statistics/methodology, responsible conduct of research, and rigor and reproducibility. Preference is given to students who have completed doctoral qualifying examinations, thereby selectively investing resources in committed, productive students who have already completed major program milestones. Proposed changes to the program include: (a) leveraging enhanced capacity at UF to focus more strongly on interventions to be used with CA, MCI and AD; (b) increasing mechanisms for trainees to engage in collaborative team science; and (c) introducing a mentor-in-training role to create a diverse pipeline of future mentors. Progress to date: Of 37 trainees to date, 27 (73%) were women, 11 (30%) were members of under-represented racial/ethnic minorities. Twelve (12) trainees remain in training (student, intern, post-doctoral fellow). Twenty-five (25) trainees are post-training with 22 (88%) in research intensive or research related positions, including :16 (64%) associate/assistant professors, 3 (12%) research scientists and 2 (8%) administrators; 17 (68%) in Research 1, 2 (8%) in Research 2, and 3 (12%) in VA institutions.