Mechanisms of serotonergic and triptan mediated analgesia within the midbrain

慢性疼痛需要多种药物干预，这些往往是无效的。这些药物包括那些作用于一组不同的细胞表面蛋白质，称为血清素受体。该项目将使用细胞和整体动物技术来研究这些药物如何在大脑内的内在疼痛和焦虑控制系统中起作用，以确定具有增强疗效和减少副作用的新型镇痛药物疗法。

Chronic pain requires multiple pharmacological interventions and these are often ineffective. These drugs include those which act on a diverse group of cell-surface proteins, called serotonin receptors. This project will use cellular and whole animal techniques to examine how these agents act within intrinsic pain and anxiety control systems within the brain in order to identify novel analgesic pharmacotherapies with enhanced efficacy and reduced side effects.