Realistic models of gastrointestinal bioelectromagnetism

描述（由申请人提供）： 随着还原论生物医学科学成功地在分子水平上阐明了更多的细节，数学建模框架将变得越来越重要，以科普这种数据爆炸，并将整合的整个器官功能与利用这种分子知识的生物病理学详细机制联系起来。这项研究有两个主要的长期目标。第一个是开发一个可扩展的解剖学和生物病理学为基础的建模框架，可用于整合的生理，解剖和医学知识的胃肠道（GI）系统。第二个目标是集中在两个主要的胃肠道疾病，影响了大量的人在美国，即肠缺血和糖尿病胃轻瘫的综合建模框架。先前的研究表明，使用多通道超导量子干涉仪（SQUID）磁力计记录胃肠道电活动的磁场，可对胃肠道平滑肌的生理状态进行无创、非接触式评估。我们将结合联合收割机多通道SQUID和皮肤电极测量与解剖学为基础的综合计算机模型，以调查间和受试者内的影响，肠缺血和胃轻瘫对胃肠道电活动的非侵入性。我们假设，由此产生的整合的解剖和生理生物物理特性将作为一个基础，更完整地了解胃肠道系统，并将有助于检测和诊断，并最终在治疗胃肠道疾病。这必然是一个最初涉及四个小组的合作项目（范德比尔特大学的活态物理组、范德比尔特大学的外科学系、内华达州大学医学院的生理学和细胞生物学系以及奥克兰大学的生物工程研究所），并将基于生物药理学的集成建模的专业知识与生理、在胃肠系统功能方面的临床和研究专长。

DESCRIPTION (provided by applicant): As reductionist biomedical science succeeds in elucidating ever more detail at the molecular level, a mathematical modeling framework will become increasingly important to cope with this explosion of data and to relate integrated whole organ function to underlying biophysically detailed mechanisms that exploit this molecular knowledge. The proposed research has two primary long term objectives. The first is to develop an extensible anatomically and biophysically based modeling framework that can be used to integrate the physiological, anatomical and medical knowledge of the gastrointestinal (GI) system. The second objective is to focus this integrative modeling framework on two major diseases of the GI tract which affect a significant number of people in the United States, namely intestinal ischemia and diabetic gastroparesis. Prior research has shown that recordings of the magnetic field from gastrointestinal electrical activity using multichannel Superconducting QUantum Interference Device (SQUID) magnetometers provides a noninvasive, noncontact assessment of the physiological state of the GI smooth muscle. We will combine multichannel SQUID and cutaneous electrode measurements with anatomically based integrative computer models to investigate the inter- and intra-subject effects of intestinal ischemia and gastroparesis on GI electrical activity noninvasively. We hypothesize that the resulting integration of anatomical and physiological biophysical properties will serve as a basis for a more complete understanding of the gastrointestinal system and will aid in the detection and diagnosis and ultimately, in the treatment of gastrointestinal disorders. This is necessarily a collaborative project that initially involves four groups (the Living State Physics Group at Vanderbilt University, The Department of Surgery at Vanderbilt University, the Department of Physiology and Cell Biology, University of Nevada School of Medicine and the Bioengineering Institute at The University of Auckland) and combines expertise in integrated biophysically based modeling with physiological, clinical and research expertise in the function of the gastrointestinal system.