Core 2: Biospecimen, Metabolomics, and Pathology Core

项目摘要/摘要 生物医学、代谢组学和病理学核心(BMP核心)的目标是创建一个联合的、多学科的 机构资源，以提供高质量的、临床注释的生物样品、代谢组学分析和 对本次孢子应用的所有研究项目以及未来孢子赞助的所有研究项目进行专家病理学审查 DRP和CEP项目，同时作为更广泛的子宫内膜的无与伦比的生物样品资源 癌症研究社区。核心中心将为每个人提供特定的组织和生物样本相关服务 孢子项目。此外，BMP Core还将预期在WUSTL建立一个生物质学资源库， OUHSC和UNM通过在参与机构中确定新的和复发的子宫内膜癌病例 并促进同意和采购过程。这些患者的组织和液体生物标本将 通过利用现有生物信息库的广泛基础设施 参与机构。临床数据将通过与现有数据的整合和扩展进行前瞻性收集 临床数据库。与生物统计核心的互动将确保维持的数据表的互操作性 在每个机构。BMP核心将提供通往世界级代谢组学和同位素中心的通道 在WUSTL追踪。经过验证的样品处理和保存方法，重点是优化 将提供代谢分析，以增加收集的所有生物样本的科学效用。一个 透明和公平的机制，宣传现有的生物检疫资源并对任何请求进行评估 他们的使用将会得到实施。因此，BMP核心将补充现有的癌症中心资源 以集中的专业知识和努力全面收集、注释、质量审查和分发 专门用于翻译子宫内膜癌研究的生物样品。

PROJECT SUMMARY/ABSTRACT The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi- institutional resource to provide high-quality, clinically annotated biospecimens, metabolomic analyses, and expert pathology review to all research projects in this SPORE application as well as future SPORE-sponsored DRP and CEP projects, while serving as an unparalleled biospecimen resource to the broader endometrial cancer research community. The Core will provide specific tissue and biosample-related services for each SPORE project. In addition, the BMP Core will prospectively build a biospecimen resource bank at WUSTL, OUHSC, and UNM by identifying cases of new and recurrent endometrial cancer at the participating institutions and facilitating the consent and procurement process. Tissue and fluid biospecimens from these patients will be collected, processed, and stored by leveraging the extensive infrastructure of existing biorepositories at the participating institutions. Clinical data will be collected prospectively by integrating with and extending existing clinical databases. Interactions with the Biostatistics Core will ensure interoperability of data tables maintained at each institution. The BMP Core will provide access to the world-class Center for Metabolomics and Isotope Tracing at WUSTL. Validated methods for sample processing and preservation, focused on optimizing metabolic analyses, will be provided to increase the scientific utility of all biospecimens collected. A transparent and equitable mechanism to publicize existing biospecimen resources and evaluate any request for their use will be implemented. As such, the BMP Core will supplement existing cancer center resources with focused expertise and effort to comprehensively collect, annotate, quality review, and distribute biospecimens specifically for translational endometrial cancer research.