DRUG DISCOVERY RESEARCH CORE: AIDS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 关于艾滋病：药物发现研究（DDR）的总体目标是通过集中和协调的研究合作，加强佛罗里达A&M大学药物发现的研究基础设施。尽管化学治疗剂及其作用机制有了重大发现，但对具有用于治疗某些癌症和感染性疾病的新作用机制的新化学实体的需求仍然很高。 因此，计划通过研究合作积极开发新的药物及其作用机制。 这项活动的另一个动力是采取措施，解决参与药物发现研究的少数民族研究人员数量持续不均衡的问题。在历史上的黑人学院和大学植入药物发现研究的困难是由于缺乏足够的资源，训练有素的调查人员和药物发现的研究基础设施。 为了实现这一目标，DDR制定了以下五个具体目标，以增加药物发现研究活动：加强药物发现研究合作活动;建立核心分析仪器实验室;增强基于计算机的分子建模实验室;增加少数民族研究人员和支持药物发现领域的试点研究项目。这些活动的预期成果是对大学的普世研究产生积极影响，并通过研究人员之间的合作和有限资源的共享，提高教师的研究竞争力。 该大学还预计，少数民族研究人员的数量和出版成果的生产力将增加，从而增加研究资金的机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS: The overall goal of the Drug Discovery Research (DDR) is to strengthen the research infra-structure for drug discovery at Florida A&M University through research collaboration in a focused and coordinated effort. Despite significant discovery of chemotherapeutic agents and their mechanisms of action, the need for new chemical entities having new mechanisms of action for the treatment of certain cancer and infectious diseases remain high. Therefore, an aggressive exploitation of new agents and their action mechanism is planned through research collaboration. Another impetus for this activity is to take a step toward a remedy for the persistent disparity in the number of minority investigators involved in drug discovery research. The difficulty in implanting drug discovery research at historically black colleges and universities is due to the lack of adequate resources, trained investigators and research infrastructure for drug discovery. To realize this goal, the DDR has developed the following five specific aims to increase drug discovery research activities in this application: enhance drug discovery research collaboration activities; establish a core analytical instrument laboratory; augment computer-based molecular modeling laboratory; increase minority investigators and support pilot research projects in the area of drug discovery. The expected outcomes of these activities are the positive impact on university research in ecumenical and increased faculty research competitiveness through collaboration and sharing of limited resources among the investigators. The University also expects an increased number of minority researchers and productivity in publishing results that lead to an increase in research funding opportunities.