Neurobiological Aspects of Aging

描述（由申请人提供）：本指导临床科学家发展计划的目的是支持在与衰老相关的神经科学学科中优秀的医生培训生的职业发展，使他们能够独立研究。培训将作为一个联合项目进行，利用当地神经科学界的多样化和广泛的资源，包括加州大学圣地亚哥分校、斯克里普斯研究基金会、索尔克研究所和伯纳姆基金会。该项目的优秀申请者将从加州大学圣地亚哥分校神经科学系临床神经学项目的应届毕业生和全国神经学培训项目中招募。每年申请1个名额，为期5年，共计5个培训职位。该项目将由神经科学部门管理，这是一个基础科学-临床联合部门。该学院在神经系统衰老研究的遗传、分子、细胞、系统、行为和建模方面具有相当大的实力。该学院还积极从事转化研究，从而直接影响人类疾病的治疗。该培训计划将为被任命者提供三种类型的学术经验

DESCRIPTION (provided by applicant): The purpose of this Mentored Clinical Scientist Development Program is to support the career development of outstanding physician trainees in an aging-related neuroscience discipline, leading-to-research independence. Training will be conducted as a joint program taking advantage of the diverse and extensive resources of the local neuroscience community, including the University of California-San Diego, Scripps Research Foundation, the Salk Institute, and the Burnham Foundation. Outstanding applicants for the program will be recruited both locally from graduating residents of the clinical neurology program in the Department of Neurosciences at UCSD, and from neurology training programs nationally. 1 slot per year is requested for a 5 year period, totaling 5 training positions. The program will be administered by the Department of Neurosciences, a joint basic science-clinical department. The faculty possesses considerable strength in the genetic, molecular, cellular, systems, behavioral and modeling aspects of nervous system aging research. The faculty are also active in translational research, thereby directly impacting the treatment of human disease. The training program will provide appointees three types of academic experiences to lead to research independence: 1) Basic neuroscience training, accomplished by formal Neuroscience Graduate Program course work and laboratory research rotations, 2) a 3-4 year period of intensive mentored research, and 3) a continuous curriculum of symposia, coursework in aging, and lectures. Trainees who do not have a Ph.D. degree will have the opportunity to enroll in the UCSD Neuroscience Graduate Program and earn a Neuroscience doctoral degree The training program intends to expose the trainees to a breadth of neuroscience topics that are required to approach aging-related questions from a comprehensive and scholarly vantage point, ranging from the study of gene expression to whole systems/behavioral approaches. Individual trainees will then choose a discipline within which to focus and foster a career research topic.