Examination of emotion regulation strategy use in an outpatient treatment program for adolescents with co-occurring disorders

项目摘要/摘要 大多数青少年(61%-88%)在接受酒精使用障碍(AUD)治疗时有共同发生的 精神病学诊断。患有AUD和共生诊断的年轻人表现出较差的一般功能和 与仅有AUD的患者相比，治疗结果更差。不幸的是，青少年AUD的治疗 落后于成人，并且显示出较小的效果尺寸。为了改善对这一人群的干预，有一个 需要了解青少年AUD治疗的方式和原因，并确定跨诊断治疗 可以同时针对多种疾病症状的机制。情绪调节技能的使用是其中之一 这样的机制。这项建议利用生态瞬时评估(EMA)来研究 情绪调节技能在治疗环境中的使用，以及检查其对相关AUD和 共发障碍的治疗结果。拟议的研究将在一个 接受AUD强化门诊计划的青少年(13-18岁)的社区样本 正在发生的疾病。考虑到EMA研究和少量工作所需的成本和劳动密集型资源 K99项目将包括一项试验研究，以测试该项目的可行性和 将确定遵守的障碍，并将完善议定书。(目标1a-1c)。 R00项目(N=80名青少年)将由为期10周的研究组成，在此期间参与者将完成 两份为期3周的EMA报告。R00项目的目标是检查预期的瞬间 情绪调节技能使用与瞬时治疗结果之间的关系(目标2)，以表征 情绪调节技能在治疗中使用的变化程度(目标3a)，并检查是否发生变化 在情绪调节方面，技能的使用与治疗结果的变化相一致(目标3b)。 调查结果将作为这一工作领域更大规模的NIAAA R01赠款提交的试点数据。重要的是，这 K99/R00应用程序将作为Jenzer博士发展为独立的 科学家。导师(米兰达博士、马吉尔博士、韦斯博士、利特博士)致力于候选人的培训，每个人都将 为研究和培训计划提供独特的专业知识。

PROJECT SUMMARY/ABSTRACT Most adolescents (61-88%) who present to treatment with alcohol use disorder (AUD) have a co-occurring psychiatric diagnosis. Youth with AUD and a co-occurring diagnosis exhibit poorer general functioning and worse treatment outcomes compared to those with AUD alone. Unfortunately, treatments for adolescent AUD lag behind those for adults and show small effect sizes. To improve interventions for this population, there is a need to understand how and why adolescent AUD treatments work and to identify transdiagnostic treatment mechanisms that can target symptoms of multiple disorders simultaneously. Emotion regulation skill use is one such mechanism. This proposal leverages ecological momentary assessment (EMA) to study the change in emotion regulation skill use within a treatment context as well as examine its influence on relevant AUD and co-occurring disorder treatment outcomes. The proposed research will examine these processes within a community sample of adolescents (aged 13-18) undergoing an intensive outpatient program for AUD and co- occurring disorders. Given the cost and labor-intensive resources required for EMA research and the little work using EMA with this population, the K99 project will consist of a pilot study to test the feasibility and acceptability of the EMA protocol, will identify barriers to compliance, and will refine the protocol. (Aims 1a-1c). The R00 project (N = 80 adolescents) will consist of a 10-week study during which participants will complete two 3-week bursts of EMA reports. Aims of the R00 project are to examine prospective momentary associations between emotion regulation skill use and momentary treatment outcomes (Aim 2), to characterize the extent of change in emotion regulation skill use across treatment (Aim 3a) and examine whether changes in emotion regulation skill use coincide with changes in treatment outcomes across treatment (Aim 3b). Findings will serve as pilot data to a larger NIAAA R01 grant submission in this area of work. Importantly, this K99/R00 application will serve as foundational training for Dr. Jenzer's development as an independent scientist. Mentors (Drs. Miranda, Magill, Weiss, Litt) are committed to the candidate's training and each will provide unique expertise to the research and training plan.