Linking Clinical Phenotypes and Molecular Underpinnings of Addiction

描述（由申请人提供）： 培训医生更好地了解和治疗成瘾性疾病是至关重要的使命的NIDA。尽管最近在神经科学方面取得了重大进展，但由于临床/生物学相关性的不完全阐明以及缺乏受过科学培训的成瘾精神病学家，实践中的应用受到限制。我们提出成瘾精神病学跨学科研究培训（APIRT）计划，研究密集型的范德比尔特大学医学中心（VUMC）和历史上的非裔美国人Meharry医学中心（MMC）之间的联盟，为成瘾精神病学家提供培训，在越来越专业的临床实践，神经影像学方法和强大的遗传范式的时代，所有这些都是在高通量分子技术和信息科学前所未有的进步的背景下进行的。我们寻求每年两名学员的支持，分别来自MMC和VUMC精神病学部门，为期两年的学习课程超出了协调的学术丰富的成人和成瘾精神病学培训轨道，导致临床调查科学硕士（MSCI）。对于MSCI，学员必须完成一个跨学科的临床研究项目，严格的教学法，并申请继续研究支持NIDA。APIRT计划还为学员提供独特的实验室接触，促进对基础研究范围（潜力和局限性）的理解，而不是成为基础研究人员的能力。学员还将接受由参与单位赞助的个性化生物统计和生物信息学培训以及跨学科培训。APIRT计划的目标是提供培训，以有意义地调查-跨学科团队，在真实的世界环境中使用高性能计算研究方法-临床观察与神经成像和基因组学/蛋白质组学新兴技术的生物数据之间的联系，以改进成瘾和并发症患者的诊断和治疗。APIRT由一组互动的研究人员与NIDA和其他NIH的支持，完善的和现成的研究核心计划，并坚定地致力于Meharry/范德比尔特联盟，其重点是研究，教学和临床护理，以解决医疗保健的差距和发展学术领导人从代表性不足的少数民族人口。

DESCRIPTION (provided by applicant): Training physicians to better understand and treat addictive disorders is vital to the mission of NIDA. In spite of significant recent advances in neuroscience, applications to practice have been limited by incomplete elucidation of clinical/biological correlates and a paucity of addiction psychiatrists with scientific training. We propose the Addiction Psychiatry Interdisciplinary Research Training (APIRT) Program, a consortium between the research intensive Vanderbilt University Medical Center (VUMC) and the historically African American Meharry Medical Center (MMC), to provide training for addiction psychiatrists embarking on combined clinical/research careers in an era of increasingly specialized clinical practice, neuroimaging approaches, and powerful genetic paradigms, all in the context of high throughput molecular technologies and unprecedented advances in information science. We seek support for two trainees per year, one each from MMC and VUMC Departments of Psychiatry, for a two year course of study beyond a coordinated academically enriched Adult and Addiction Psychiatry training track, leading to the Master of Science in Clinical Investigation (MSCI). For the MSCI, trainees must complete an interdisciplinary clinical research project, rigorous didactics, and an application for continued research support to NIDA. The APIRT program also offers unique laboratory exposure to trainees that foster an understanding of the scope (potential and limitations) of fundamental research, rather than the capacity to become basic researchers. Trainees will also receive individualized biostatistical and bioinformatics training, and interdisciplinary training sponsored by the participating units. The objective of the APIRT Program is to provide training to meaningfully investigate - in interdisciplinary teams, using high-performance computing research methodologies in real world settings - the linkages between clinical observations and biological data from emerging technologies in neuroimaging and genomics/proteomics for refining diagnosis and treatment of patients with addiction and co-occurring disorders. APIRT is enhanced by an interactive group of investigators with NIDA and other NIH support, well-established and readily available research core programs, and a strong commitment to the Meharry/Vanderbilt Alliance, with its emphasis on research, teaching, and clinical care to address health care disparities and developing academic leaders from under-represented minority populations.