New York State BD-STEPS: Component A and B

项目摘要 纽约州出生缺陷研究和预防中心(NYSCBDRP)建议继续其 进行流行病学研究以确定出生缺陷的原因的良好记录 参与出生缺陷研究以评估妊娠暴露(BD-STEPS)。NYSCBDRP已经 是CDC合作的全国出生缺陷预防研究(NBDPS)和BD- 自1996年以来一直步步紧逼。NYSCBDRP位于纽约州卫生局(NYSHOH)出生 缺陷登记处，并与奥尔巴尼大学公共学院建立了密切的合作关系 健康。该项目的具体目标是：(1)从两个方面确定出生缺陷病例和对照 纽约州地理和社会人口统计多样化的集水区；(2)开展 关于特定出生缺陷的非遗传危险因素的流行病学调查，包括药物， 慢性病和传染病、职业因素、健康的社会决定因素以及健康公平 在3.5年内至少发表了7篇出版物和7篇演讲；(3)贡献了残留的新生儿血迹和 调查出生缺陷的遗传因素；(4)将个体与纽约国家电子疾病联系起来 监测系统，以确定和表征怀孕前和怀孕期间感染对 (5)评估和发展BD-Steps现有的和新的信息收集模式；以及 (6)通过提供实习和论文/学位论文数据，指导和培训未来的出生缺陷研究人员 奥尔巴尼大学公共卫生学院的研究生和初级学生的培训机会 NYSCBDRP分析师。从其在NYSCBDRP中的地位来看，NYSCBDRP将利用相当大的 通过捐赠员工时间、特权访问个人医疗记录、出生缺陷等资源 登记，传染病监测系统，以及与世界著名的沃兹沃斯中心的联系 基因研究实验室。NYSCBDRP已经成功地实施了NBDPS和BD- Steps研究和进行出生缺陷研究，BD-Steps参与率最高，甚至更多 由纽约作者领导的50多份NBDPS/BD-STEPS分析的同行评议出版物。NYSCBDRP是 具备继续成功实施业务拓展步骤的能力，有助于增加对风险的认识 影响出生缺陷的因素，并提供预防策略。

Project Summary The New York State Center for Birth Defects Research and Prevention (NYSCBDRP) proposes to continue its strong record of conducting epidemiologic research to identify the causes of birth defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS). The NYSCBDRP has been a major contributor to CDC’s collaborative National Birth Defects Prevention Study (NBDPS) and BD- STEPS since 1996. The NYSCBDRP is situated in the New York State Department of Health (NYSDOH) Birth Defects Registry and enjoys a strong collaborative relationship with the University at Albany School of Public Health. The Specific Aims of this project are to: (1) identify birth defect cases and controls from two geographically and sociodemographically diverse catchment areas in New York State; (2) conduct epidemiologic investigations on non-genetic risk factors for specific birth defects, including medications, chronic and infectious disease, occupational factors, social determinants of health, and health equity, resulting in at least 7 publications and 7 presentations over 3.5 years; (3) contribute residual newborn bloodspots and investigate genetic factors for birth defects; (4) link individuals to the NYS National Electronic Disease Surveillance System to ascertain and characterize the impact of infections before and during pregnancy on birth defects; (5) evaluate and develop existing and novel modes of information collection for BD-STEPS; and (6) mentor and train future birth defects researchers by offering internships and thesis/dissertation data for graduate students at the University at Albany School of Public Health and training opportunities for junior NYSCBDRP analysts. From its position within the NYSDOH, the NYSCBDRP will leverage considerable resources through donated staff time, privileged access to individual medical records, the Birth Defects Registry, infectious disease surveillance systems, and affiliation with the world-renowned Wadsworth Center laboratory for genetic studies. The NYSCBDRP has demonstrated success implementing the NBDPS and BD- STEPS studies and conducting birth defects research, with the highest BD-STEPS participation rate and more than 50 peer-reviewed publications of NBDPS/BD-STEPS analyses led by an NYS author. The NYSCBDRP is well-positioned to continue successfully implementing BD-STEPS, helping to increase knowledge of risk factors for birth defects and inform prevention strategies.