Effects of Social Networks and Policy Context on Health among Older Sexual and Gender Minorities in the US South

项目总结 没有提出任何修改建议。 引言 本申请书为《性与性别少数群体研究行政补编》(SGM) Popular(非-OD-22-032)颁发给家长奖，《社会网络和政策背景对健康的影响》 在美国南部较年长的性少数群体和性别少数群体中，“(R01AG063771)。 这个应用程序建议将家长奖的现有数据收集扩展到一个老年性爱小组 和性别少数(SGM)成年人纳入新的客观认知功能衡量标准。父辈 该奖项已经包括自我报告的认知功能和对认知相关结果的分析 在母公司奖励的范围内。 因此，这项建议寻求扩大与特别报告员有关的数据和关于健康的研究问题的范围 以及通过扩大措施来实现老龄化，而这些措施在这些人群中是不存在的。正如我们在 策略，目前还没有研究直接测量自我认同的认知功能 SGM老年人，无论关系状态如何，只有一项横断面研究测试了认知 包括老年人(20-65岁)的样本中不同性别和性取向的能力 工作很少 SGM人群中自我报告的认知老化能够分解SGM人群的经验和结果 由于样本量小，SGM人群的身份或其他暴露(例如，负面生活经历)。几个 最近的报告，包括关于LGBTQI+股权的2023年联邦证据议程，突显了缺乏关于 可分类以考虑组内结果和机制差异的可持续发展机制人口2 收集认知功能的新的客观衡量标准，以及已经很稳健的调查和 范德比尔特大学社交网络、老龄化和政策研究(VUSNAPS)的生物标志物基础设施将 通过在包括Partnered的SGM样本中直接测量认知功能来解决这两个问题 没有伴侣的老年人足够大，可以发现顺性和性别之间的差异 变性人/性别多样化的SGM人群，以及男/女同性恋和双性恋人群。 此外，这些认知功能测量的集合将有助于对关键 VUSNAPS研究网络成员积极寻求的问题，包括： 1.SGM和非SGM老年人在认知功能和认知轨迹上是否存在差异 生活？ 2.被试在认知功能和认知轨迹上是否存在群体内差异 SGM人口？ 3.这些差异是否可归因于少数人通过炎症、免疫等方式暴露于压力 调节失调、精神困扰和睡眠障碍的途径？ 4.认知功能减退的SGM老年人的需求与患有和 没有伴侣/配偶和亲属关系？ 虽然没有特别申请资金用于这一补充、培训和对Deia的指导 受训人员仍然是VUSNAPS的主要目标。该项目已在 培训各种未来的保健专业人员，包括4名博士后实习生、3名研究生和15名 本科生。我们已经完成了多样性补充(R01AG063771-02S1)，并拥有 积极提供多元化指导补充资料(R01AG063771-04S2)，旨在扩大 通过为25名初级、博士后和研究生研究人员提供为期两天的研讨会，解决健康差距问题 老化和生物标记物在健康差距研究中的使用。我们的工作还产生了多个新的培训 应用程序，包括R36(Tran)、K01(Barbee)和两个LRP应用程序(Lampe和Barbee)。 总之，我们在此应用程序中概述的活动将极大地提高可用日期的质量 SGM人群中的认知老龄化，扩大NIH对父母奖励的投资的影响，改善 SGM人群参与老龄化研究的多样性和包容性，为培训SGM健康提供新的机遇 差异研究人员，并为SGM认知老化的新领域驱动研究做出贡献。

PROJECT SUMMARY No changes being proposed. INTRODUCTION This application is for an Administrative Supplement for Research on Sexual and Gender Minority (SGM) Populations (NOT-OD-22-032) to the parent award, ““Effects of Social Networks and Policy Context on Health among Older Sexual and Gender Minorities in the US South,” (R01AG063771). This application proposes to extend the parent award’s existing data collection among a panel of older sexual and gender minority (SGM) adults to include new objective measures of cognitive functioning. The parent award already includes self-reported cognitive functioning and analyses of cognition-related outcomes are within the scope of the parent award. As such, this proposal seeks to extend the range of SGM-related data and research questions on health and aging through the expansion of measures that are not available in this population. As we note in the strategy, there are currently no studies that directly measure cognitive functioning in self-identified SGM older adults regardless of relationship status and only one cross-sectional study has tested cognitive abilities across gender and sexual orientation in a sample inclusive of older adults (age 20-65).1 Very little work on self-reported cognitive aging in SGM populations is able to disaggregate the experiences and outcomes of SGM people by identity or other exposures (e.g., negative life experiences) due to small sample sizes. Several recent reports, including the 2023 Federal Evidence Agenda on LGBTQI+ Equity, highlight the lack of data on SGM populations that can be disaggregated to consider within-group variation in outcomes and mechanisms.2 The collection of new objective measures of cognitive functioning alongside the already-robust survey and biomarker infrastructure of the Vanderbilt University Social Networks, Aging, and Policy Study (VUSNAPS) will address both concerns by directly measuring cognitive functioning in a SGM sample that includes partnered and unpartnered older adults that is large enough to detect differences among cisgender and transgender/gender diverse SGM people, and among gay/lesbian and bisexual people. Additionally, these collection of cognitive functioning measures would contribute to new research on key questions that members of the VUSNAPS research network motivated to pursue, including: 1. Do SGM and nonSGM older adults differ in cognitive functioning and cognition trajectories in later life? 2. Are there within-group differences in cognitive functioning and cognition trajectories among the SGM population? 3. Are these differences attributable to minority stress exposures via inflammation, immune dysregulation, mental distress, and sleep disruption pathways? 4. Are the needs of SGM older adults experiencing cognitive decline different for those with and without partners/spouses and kin ties? Although no funds are specifically requested for training on this supplement, training and mentorship of DEIA trainees continues to be a primary goal of the VUSNAPS. The project has made significant investments in the training of diverse future health professionals, including 4 postdoctoral trainees, 3 graduate students, and 15 undergraduate students. We have completed a Diversity Supplement (R01AG063771-02S1) and have an active a Diversity Mentoring Supplement (R01AG063771-04S2) that aims to expand training opportunities in SGM health disparities by providing a two-day workshop to 25 junior, postdoc, and graduate researchers SGM aging and use of biomarkers in health disparities research. Our work has also generated multiple new training applications, including an R36 (Tran), a K01 (Barbee), and two LRP applications (Lampe and Barbee). Together, the activities we outline in this application will substantially improve the quality of date available on cognitive aging among SGM populations, extend the impact of NIH investments in the parent award, improve diversity and inclusion of SGM people in aging research, provide new opportunities for training SGM health disparities researchers, and contribute to new field-driving research on SGM cognitive aging.