Calculating Dynamic CMRO2 Changes Using CBF & BOLD fMRI

描述(申请人提供)：由神经元活动产生的脑氧耗代谢率(CMR02)的变化与脑组织功能的能量学直接相关。这些变化导致了血氧水平依赖(BOLD)的fMRI信号，也是BOLD fMRI在多学科脑功能研究中广泛使用的部分原因。从BOLD fMRI数据中确定CMR02反应的幅度和动力学不仅对于揭开BOLD反应的基础非常有意义，而且对于理解大脑功能也非常有意义。该方案的目的是利用fMRI数据确定神经激活引起的CMR02的动态变化，并研究瞬时氧运输和消耗的假设是否适用于此目的。为此，无创和有创测量脑血流量(CBF)、脑血容量(CBV)、组织氧分压(PO2tiss)。在已建立的大鼠躯体感觉模型中，将使用MRI(9.4特斯拉扫描仪)和非MRI方法获取固有信号(OIS)的光学成像和BOLD测量。作为这个拟议项目的结果，将开发并验证一种使用功能磁共振数据来确定CMR02动态变化的方法。这些方法可以在临床环境中用于评估大脑和其他器官的组织活性和功能。

DESCRIPTION (provided by applicant): Changes in the cerebral metabolic rate of oxygen consumption (CMR02) produced by neuronal activity are directly related to the energetics of brain tissue function. These changes contribute to the blood oxygenation level dependent (BOLD) fMRI signal and have been partly responsible for the extensive use of BOLD fMRI in multi-disciplinary studies of brain function. Determining the magnitude and dynamics of CMR02 responses from BOLD fMRI data has been of great interest not only to unravel the underpinning of the BOLD response, but also in the understanding of brain function. The goals of this proposal are to determine the dynamic changes in CMR02 elicited by neural activation using fMRI data and investigate whether the assumption of instantaneous oxygen transport and consumption is valid for this purpose. To this end, non-invasive and invasive measurements of CBF, cerebral blood volume (CBV), tissue oxygen tension (PO2tiss). optical imaging of intrinsic signals (OIS) and BOLD measurements will be acquired using MRI (9.4 Tesla scanner) and non-MRI methodologies in a well-established rat somato-sensory model. As a result of this proposed project, a method to determine the dynamic changes in CMR02 using fMRI data will be developed and validated. These methods can be used in the clinical setting to assess tissue viability and function in the brain as well as other organs.