STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF ALPHA-PINENE

本合同的目的是为国家毒理学计划（NTP）危害识别（或危害评估）活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。该项目涉及通过吸入暴露对选定化学品进行慢性前和慢性研究。已提交偏二氯乙烯和α-蒎烯的14天和90天研究报告。偏二氯乙烯的2年研究已经完成并报告。由于管理层决定不进行该研究，因此取消了为期2年的α-蒎烯研究。 致癌性;毒性;生物测定; F344大鼠; B6 C3 F1小鼠;偏二氯乙烯; α-蒎烯

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification (or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This project involves prechronic and chronic studies of selected chemicals via inhalation exposure. The 14-day and 90 day study reports have been submitted for vinylidene chloride and alpha-pinene. The 2-year study of vinylidene chloride has been completed and reported. The 2-year study for alpha-pinene has been canceled as a result of a management decision not to conduct the study. Keywords Carcinogenicity; toxicity; bioassay; F344 rats; B6C3F1 mice; vinylidene chloride; alpha-pinene