ENGINEERING OF CANCER NANOTECHNOLOGIES FOR HIGH-THROUGHPUT FABRICATION

摘要构成NSBCC技术核心的纳米技术是实现这两个目标的设备 基础癌症研究，并最终用于癌症患者的临床护理。然而，它们是相似的 对于其他“高”纳米技术--它们还不适合大规模生产。许多问题都是 必须解决的问题需要基础科学和工程学的结合--必须解决的问题 在这些技术商业化之前。NSBCC的主要影响以及 NCI的纳米技术目标，只有在以下情况下才能感受到 CCNE最终被广泛使用，NSBCC处于非常有利的地位，可以开始规划 那就是现在。在这个项目中，我们研究了大规模生产背后的基础科学 纳米传感器和我们确定的复制过程，当完全开发时，应该能够实现质量 制作。我们的目标还包括将这些纳米传感器与耐溶剂和抗生物污垢的产品相结合。 微流体学，以及这些传感器的绝对定量与我们的黄金标准，这将 是使用特定的定量ICAT质谱学技术测量的一组血清蛋白质。 该项目的目标是使我们的纳米技术能够广泛应用于癌症。 研究人员和癌症临床医生。

Abstract The nanotechnologies that form the technology core of the NSBCC are enabling devices for both fundamental cancer research, and eventually for clinical care of cancer patients. However, they are similar to other 'high' nanotechnologies - they are not yet amenable to mass production. Many of the issues that must be solved require a mixture of fundamental science and engineering - problems that must be solved before commercialization of these technologies is likely to occur. The major impact of the NSBCC, and of the NCI's nanotechnology goals, will only be felt if the tools and technologies that are developed within the CCNE's are eventually made broadly available, and the NSBCC is in a terrific position to start planning for that right now. In this Project, we work out the fundamental science behind the mass production of nanosensors and we identify replication processes that, when fully developed, should enable mass productions. Our aims also include the integration of those nanosensors with solvent and biofouling-resistant microfluidics, and the absolute quantitation of those sensors against our gold standard, which will be a panel of serum-proteins measured using a particular quantitative ICAT mass spectrometry technique. The goal of this project is to enable the wide-spread application of our nanotechnologies to cancer researchers and to the cancer clinicians.