Neurological Emergencies Treatment Trials (NETT) Network; U. of Mn. Hub

描述（由申请人提供）：有效研究神经紧急情况的流行病学，病理生理学和潜在创新治疗方法的能力一直很困难，因为许多情况很少发生。这些事件的罕见性往往降低了招募足够数量的患者参加临床试验的能力。目前对许多神经急症的治疗方法往往研究不足或不令人满意。考虑到这些问题，并且出于改善神经急症患者急诊护理的真诚愿望，神经急症治疗试验（NETT）网络已被提出。本提案拟在明尼苏达大学医学院急诊医学系建立NETT网络中心。作为多个城市和农村、学术和社区ED辐条的协调中心，该中心将促进和确保国家NETT网络提出的患者成功招募和入组临床试验。该中心将促进相关研究成果的传播，目标是直接影响神经急症患者的护理。本建议第一年的具体目标是：1. 在明尼苏达大学急诊医学系建立枢纽基础设施，以促进和开展神经临床试验，目标是确定有效的新治疗方法，否则将是毁灭性的病理。这将包括1)枢纽领导和行政基础设施的发展；2)与拟议辐条的研究物流合作协议；3) Spoke研究的必要支持制度、政策和程序；4) Spokes的培训模块，涉及研究原则和实践，研究中的人类受试者保护和具体的研究方案。2. 让急诊和神经临床医生参与临床研究试验。这包括支持Spoke急诊医生和神经临床同事之间的协作和沟通，关于最佳临床实践和研究试验设计的教育，以及为患者识别和研究登记开发无缝研究流程。3. 让院前服务提供者参与研究工作。这将包括积极促进多个紧急医疗服务系统之间的沟通，并就登记情况提供反馈。4.4. 在2-5年级，根据NETT网络的要求，实施并成功执行两项临床试验。

DESCRIPTION (provided by applicant): The ability to effectively study the epidemiology, pathophysiology and potential innovative treatments for neurological emergencies has been difficult, since many occur infrequently. The rarity of these events often lessens the ability to enroll sufficient numbers of patients into clinical trials. The current therapies for many neurologic emergencies are often understudied or unsatisfactory. With these issues in mind, and because of a sincere desire to improve emergency care of patients with neurological emergencies, the Neurological Emergencies Treatment Trials (NETT) network has been proposed. This proposal is for the establishment of a NETT network Hub at the University Of Minnesota School Of Medicine, Department of Emergency Medicine. As the coordinating center for several urban and rural, academic and community ED Spokes, the Hub will promote and ensure the successful recruitment and enrollment of patients into clinical trials proposed by the national NETT Network. The Hub will promote dissemination of the resulting relevant research findings with the goal of directly impacting the care of patients with neurological emergencies. The Specific Aims for Year One of this proposal are to; 1. Create the Hub infrastructure at the University Of Minnesota Department Of Emergency Medicine to promote and conduct neurological clinical trials, with the goal of determining effective new treatments for otherwise devastating pathologies. This will include the development of 1) Hub leadership and administrative infrastructure; 2) collaborative agreements with proposed Spokes regarding research logistics; 3) necessary support systems, policies and procedures for Spoke research; 4) training modules for Spokes related to principles and practice of research, human subjects protection in research and specific research protocols. 2. Engage emergency and neuro- clinicians in clinical research trials. This includes support of collaboration and communication between Spoke emergency physicians and neuroclinical colleagues, education regarding best clinical practices and research trial designs, and development of seamless research processes for patient identification and study enrollment. 3. Engage pre-hospital providers in the research effort. This will include active promotion of communications across several emergency medical service systems and providing feedback on enrollment performance. 4.4. In Years 2-5, implement and successfully execute two clinical trials, as determined by the NETT network.