CD: Bioinformatics Core

得克萨斯大学肺癌孢子研究中心在得克萨斯大学和 西南医学中心(德克萨斯州，达拉斯，德克萨斯州)和德克萨斯大学安德森癌症 中心(UTMDACC，休斯顿，德克萨斯州)站点，涉及多名临床和基础研究人员。这些项目 生成的核心、试剂和大型数据集需要分析，并在其间共享 孢子调查员、项目和核心，还需要与其他机构的调查员共享 以及其他肺癌孢子。此外，还需要生物信息学工具来帮助存储、提取 操纵和解释这些数据。此外，这些数据还需要有可靠的备份。最后，还有一个很大的 文献中报告并存储到可访问数据库的新数据量，我们的 孢子调查员需要进入。这些需求导致了这一点的产生和发展 生物信息学核心(核心D)。此核心的目标是开发和维护数据库集成以及 在项目和核心开发的信息数据共享网站，这对许多孢子很重要 调查人员以及协助开发和使用数据分析挖掘工具，以支持 这个孢子的项目。此核心必须部署这些使能技术，以满足所有 孢子项目和核心。在孢子病理核心B中对患者信息进行去标识后， 这个核心将帮助孢子研究人员收集关于孢子实验室和临床的完整数据集 样本以及公开可用的数据集将这些数据集与孢子生物统计核心相连接 (C芯)，然后协助孢子调查员和C芯利用数据解释这些数据 采矿技术。这包括与其他肺癌孢子和机构的互动。其他设施 包括教育模块/课程、识别/测试具有潜在价值新技术/方法 所有孢子研究人员，以及提供的大量计算代码和数据库 在我们位于http://spore.swmed.edu.的服务器上软件，可通过Web或通过可下载的模块获得 表达数据分析、基因组学实验设计、文本挖掘和DNA序列分析 由孢子研究人员生产和使用。这个核心有四个具体目标：1.互联网的发展 可访问的数据库，用于数据共享和分析，以及计算生物学、资源的开发； 开发用于综合数据管理和分析的分布式计算基础设施；3. 制定并执行数据质量和保证程序。4.加强和维护孢子网 地点。这一核心由加纳博士(安博士在临床数据共享问题上的帮助)和阿尔梅达博士领导 他们都是领域专家，每个人都为这个系统开发了重要的组件，并一直 在各自机构的数据共享努力中发挥先锋作用。

The University of Texas SPORE in Lung Cancer has Projects and Cores at both the University of Texas Southwestern Medical Center (UTSW, Dallas, TX) and the University of Texas M.D. Anderson Cancer Center (UTMDACC, Houston, TX) sites that involve multiple clinical and basic investigators. These Projects and Cores and the reagents and large datasets generated need to be analyzed by, and shared between SPORE investigators, Projects, and Cores and also need to be shared with investigators at other institutions and with other Lung Cancer SPOREs. In addition, bioinformatics tools are needed to help store, extract, manipulate and interpret this data. Also this data needs to have reliable backup. Finally, there is a large amount of new data being reported in the literature and deposited into accessible databases to which our SPORE investigators need access. These needs led to the creation and development of this Bioinformatics Core (Core D). The goal of this Core is to develop and maintain database integration and a data sharing website of information developed in the Projects and Cores that is important to many SPORE investigators as well as aid in the development and use of data analysis mining tools in support of the projects of this SPORE. This Core must deploy these enabling technologies to meet the needs of all of the SPORE Projects and Cores. After de-identification of patient information in SPORE Pathology Core B, this Core will help SPORE investigators gather complete data sets on SPORE laboratory and clinical samples, as well as publicly available datasets, interface these datasets with the SPORE Biostatistics Core (Core C), and then assist SPORE investigators and CORE C in the interpretation of these data using data mining techniques. This includes interaction with other Lung Cancer SPOREs and institutions. Other facilities include educational modules/classes, identification/testing of new technologies/methods of potential value to all SPORE researchers, and the large complement of computational codes and databases made available on our servers at http://spore.swmed.edu. Software, available over the web or via downloadable modules for the analysis of expression data, genomics experimental design, text mining and DMA sequence analysis was produced and is used by SPORE researchers. This Core has 4 specific aims: 1. Development of internet accessible databases for data sharing and analysis, and development of computational biology, resources; 2. Development of a distributed computational infrastructure for integrated data management and analysis; 3. Develop and perform data quality and assurance procedures. 4. Enhance and maintain the SPORE web site. This Core is led by Dr. Garner (with aid from Dr. Ahn for clinical data sharing issues) and Dr. Almeida that are both area experts and have each developed important components for this system and have been pioneering in data-sharing efforts at their respective institutions.