Microenvironmental Impact in the Treatment of Acute Lymphoblastic Leukemia

急性淋巴细胞性白血病仍然是儿童死亡的主要原因之一，患有这种疾病的成年人的预后仍然很差。这个项目研究了如何利用对白血病发生环境的操纵来促进治疗的进步。急性淋巴细胞性白血病细胞高度依赖于骨髓细胞提供的支持，但其机制尚不清楚。干扰来自骨髓细胞的信号有可能成为一种治疗策略。

Acute lymphoblastic leukemia remains one of the leading causes of death in children and outcomes for adults with this disease remain poor. This project examines how manipulation of the environment where leukemia arises can be used to therpaeutic advancage. Acute lymphoblastic leukemia cells are highly dependent on the support provided by bone marrow cells but the mechanisms are not well understood. Disrupting signals from the bone marrow cells has potential as a therapeutic strategy.