Effect Of Intra-aortic Balloon Pump In A Canine Model Of Septic Shock

感染性休克是美国内科和外科重症监护病房最常见的死亡原因。30%死于败血症的病人都有低心输出量。本研究的目的是探讨主动脉内球囊泵反搏（IABC）在感染性休克治疗中的作用。放置主动脉内球囊泵（IABP）的目的有两个。它减少了心脏的负荷，从而减少了心脏的负荷，辅助心脏收缩，同时增强了冠状动脉的血流量，从而为心脏提供了更多的能量，增强了心脏舒张。我们有ACUC批准的方案，在具有良好特征的脓毒症低心排血量动物模型中进行IABC的对照随机生存研究。

Septic shock is the most common cause of death in medical and surgical intensive care units in the United States. Thirty percent of patients who die from sepsis are noted to have low cardiac output. The purpose of this study is to examine the role of intra-aortic balloon pump counterpulsation (IABC) in the treatment of septic shock. The goal of placing an intra-aortic balloon pump (IABP) is twofold. It reduces the afterload on the heart, thereby allowing it to do less work, assisted systole, while enhancing its coronary blood flow, thereby providing it with more energy, diastolic augmentation. We have an ACUC approved protocol to perform a controlled, randomized survival study of IABC in a well characterized low cardiac output animal model of sepsis. The overall effect of the IABC is to increase myocardial oxygen supply by increasing coronary perfusion during diastole, and decrease myocardial oxygen demand by decreasing afterload during systole. We found that intra-aortic balloon pumping resulted in a increase in survival time and a decrease in vasopressor dependence. This data has been analyzed and a manuscript has been submitted in 2007.