Sample Distribution, Processing, Banking and Database

样品和分子核心(核心B)具有以下功能： 1.建立和维护血液和骨髓标本的储存库，包括完整的细胞、血清、 在M.D.安德森接受护理或评估的MDS患者的细胞DNA、RNA和蛋白质 癌症中心。 2.将MDS患者和正常对照的样本分发给MDS P01调查人员。 3.维护显示类型的全面、预期、交互的样本数据库(在诊断时，在 AML进展等)和特征(DNA、RNA等)和可用的MDS样本及其 随后的处分。 4.通过共享血液和骨髓资源，促进MDS P01内外的协作。 5.确定患者确诊时NRAS、KRAS2和PTPN11突变的发生率 此后每3个月。 6.评估PTPN11、RAS和Flt3突变可用于量化的可能性 MDS的疾病负担。 7.测量靶向疗法的生化终点(特别是R115777)并关联 这些药效学数据与项目1中给出的治疗反应。

The Sample and Molecular Core (Core B) has the following functions: 1. Develop and maintain a repository of blood and bone marrow specimens, including intact cells, serum, cellular DMA, RNA, and protein, from patients with MDS receiving care or evaluation at M.D. Anderson Cancer Center. 2. Distribute samples from MDS patients and normal "controls" to MDS P01 investigators. 3. Maintain a comprehensive, prospective, interactive sample database showing type (at diagnosis, at AML progression etc) and characteristics (DNA, RNA etc) of available MDS samples and of their subsequent disposition. 4. Facilitate intra- and extra- MDS P01 collaborations through sharing of blood and marrow resources. 5. Ascertain the incidence of NRAS, KRAS2, and PTPN11 mutations in patients at diagnosis and every 3 months thereafter. 6. Evaluate the possibility that mutations in PTPN11, RAS, and FLT3 can be used to quantify disease burden in MDS. 7. Measure biochemical endpoints of targeted therapeutics (in particular R115777) and correlate these pharmacodynamic data with responses to therapy given in Project 1.