THE EFFECT OF OOPHORECTOMY IN POSTMENOPAUSAL WOMEN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 30%的妇女在进入绝经期时进行卵巢切除术;这些手术大多是“预防性”或“偶然性”的。然而，现在越来越多的人意识到绝经后卵巢在维持绝经后睾酮（T）水平方面的功能。在性腺功能减退的男性中，T缺乏具有显著的形态学和代谢后果，降低肌肉质量、力量、运动耐量和增加胰岛素抵抗。同样的效果也会发生在手术阉割的T缺乏的女性身上吗？为了解决这一问题，该建议概述了一个横截面检查的形态，耐力，和糖尿病的后遗症绝经后卵巢切除术，相比，妇科完整的对照组。 我们假设，在绝经后妇女，卵巢切除术的历史，以及随之而来的低T水平，创建一个倾向于减少肌肉质量，增加脂肪量，减少力量和最大运动耐量（VO 2 max），以及降低胰岛素敏感性。如果在本研究中观察到这种变化，则产生了令人信服的初步数据，用于更严格地检查偶然性或预防性卵巢切除术的不良后遗症，以及生理性T替代的潜在治疗益处。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oophorectomy is performed in 30% of women by the time they enter menopause; most of these procedures are "prophylactic" or "incidental". However there is now increasing awareness of the functionality of the postmenopausal ovary in maintaining postmenopausal testosterone (T) levels. In hypogonadal men, T deficiency has significant morphometric and metabolic consequences, decreasing muscle mass, strength, exercise tolerance, and increasing insulin resistance. Do the same effects occur in surgically castrate T-deficient women? In order to address this issue, this proposal outlines a cross-sectional examination of the morphometric, endurance, and diabetogenic sequelae of postmenopausal oophorectomy, compared to a gynecologically intact control group. We hypothesize that in postmenopausal women, a history of oophorectomy, and consequent low T levels, creates a predisposition to decreased muscle mass, increased fat mass, decreased strength and maximal exercise tolerance (VO2 max), as well as decreased insulin sensitivity. If such changes are seen in this study, then compelling preliminary data is generated for a more rigorous examination of the adverse sequelae of incidental or prophylactic oophorectomy, as well as the potential therapeutic benefit of physiologic T replacement.