CHRONIC KIDNEY DISEASE IN CHILDREN STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 国家糖尿病与消化及肾脏疾病研究所(NIDDK)的肾脏、泌尿外科和血液病学部(DKUHD)与国家神经疾病和卒中研究所(NINDS)、国家儿童健康与人类发育研究所(NICHD)和国家心肺血液研究所(NHLBI)合作，资助了一项合作协议，其中包括两个临床协调中心和一个数据协调中心，以进行一项针对慢性肾脏疾病(CKD)儿童的前瞻性流行病学研究。这项研究的主要目标是确定肾功能下降的风险因素，并确定肾功能进行性下降如何影响a)神经认知功能和行为；b)心血管疾病的风险因素；c)生长障碍及其相关发病率。共有540名患有慢性肾脏疾病的儿童(估计GFR为30-75毫升/分钟/1.73平方米)将被纳入这项为期4年的前瞻性观察研究，并接受一系列测试，以研究以下假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement including two Clinical Coordinating Centers and a Data Coordinating Center to conduct a prospective epidemiological study of children with chronic kidney disease (CKD). The primary goals of this study are to determine the risk factors for decline in kidney function and to define how a progressive decline in kidney function impacts a) neurocognitive function and behavior; b) the risk factors for cardiovascular disease; and c) growth failure and its associated morbidity. A total of 540 children with chronic kidney disease (estimated GFR 30-75 ml/min/1.73 m2) will be enrolled in this prospective observational study over 4 years and undergo a series of tests to study the hypotheses given below.