PAIN REGULATORY DYSFUNCTION IN CHRONIC PAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标1：在无痛的正常血压人群中，研究α-2肾上腺素能机制在调节静息血压和急性疼痛敏感性之间的反向关系中所起的作用。 具体目标2：确定α-2肾上腺素能功能的改变是否有助于静息血压和急性疼痛敏感性之间关系的慢性疼痛相关改变。 具体目标3：确定压力感受器敏感性的变化是否有助于改变慢性疼痛患者相对于无疼痛对照组的静息血压和急性疼痛敏感性之间的关系。具体目的4：确定慢性疼痛易感通路的慢性激活是否有助于改变慢性疼痛患者相对于无疼痛对照组的静息血压和急性疼痛敏感性之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To examine the role of alpha-2 adrenergic mechanisms in mediating the inverse relationship between resting BP and acute pain sensitivity in pain-free normotensive humans. Specific Aim 2: To determine whether changes in alpha-2 adrenergic function contribute to chronic pain-related alterations in the relationship between resting BP and acute pain sensitivity. Specific Aim 3: To determine whether changes in baroreceptor sensitivity contribute to alterations in the relationship between resting BP and acute pain sensitivity in chronic pain patients relative to pain-free controls. Specific Aim 4: To determine whether chronic pain-related activation of pain facilatory pathways contributes to alterations in the relationship between resting BP and acute pain sensitivity in chronic pain patients relative to pain-free controls.