LOSS OF EFFECT OF ASPIRIN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设：1）阿司匹林（阿萨）对离体诱导的血小板聚集的抑制作用以可预测的时间和剂量依赖性方式变化。 （2）阿萨以剂量依赖性方式抑制血栓素和前列环素的产生，并且一旦出现最大抑制作用，则随着时间的推移保持相对恒定。(3)阿司匹林急性抑制血小板在诱导聚集过程中的颗粒分泌，但这种作用在高剂量慢性给药期间并不持续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypotheses: 1)Inhibition by aspirin (ASA) of ex vivo induced platelet aggregation varies in a predictable time and dose dependent manner. (2)Thromboxane and Prostacyclin production is inhibited by ASA in a dose dependent manner and remains relatively constant over time once maximal inhibition has occurred. (3) Granule secretion by platelets during induced aggregation is inhibited by aspirin acutely but this effect does not persist during chronic administration at high