CYTOKINE LEVELS AND NEUTROPHIL PRIMING IN INFANTS WITH GASTROSCHISIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 患有腹裂的婴儿通常需要较长的住院时间，包括喂养困难和其他并发症。尽管许多研究着眼于手术类型和修复时机，但他们的许多结果是相互矛盾的。很少有研究关注这些婴儿的炎症标志物，以确定他们是否易患肠功能障碍。炎症性肠功能障碍的婴儿容易出现喂养不耐受、坏死性小肠结肠炎，需要进一步的手术干预。在一项初步研究中，我们建议评估患有腹裂的婴儿的脐带血样本，并将它们与没有腹裂的对照组婴儿的血液样本进行比较，以确定出生时是否有促炎细胞因子水平升高或中性粒细胞启动的证据。这可能表明，子宫内存在促炎状态，这可能会发现婴儿易患炎症性肠功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infants with gastroschisis often have a prolonged hospital course involving feeding difficulties as well as other complications. Though many studies have looked at type of surgery and timing of repair, many of their results are conflicting. Few studies have looked at inflammatory markers in these infants to determine if they are predisposed to bowel dysfunction. Infants with inflammatory bowel dysfunction are prone to feeding intolerance, necrotizing enterocolitis, and need for further surgical intervention. In a pilot study, we propose to evaluate cord blood samples from infants with gastroschisis and compare them with blood samples from control infants without gastroschisis to determine if there are elevated levels of pro-inflammatory cytokines or evidence of neutrophil priming at birth. This would suggest that a pro-inflammatory state exists in utero and that could potentially identify infants predisposed to post inflammatory bowel dysfunction.