ARTERIAL OXYGEN PARTIAL PRESSURE AND BLOOD OXYGENATION FROM PULSE OXIMETRY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 脉搏血氧仪已用于新生儿医学监测早产儿和足月儿的氧合数年。 主要研究者和他的工作人员进行了大量的临床研究，验证了其中两种仪器。 由于这些仪器的可靠性，它们已经取代了经皮PaO 2监测仪和直接动脉穿刺技术的大多数血液采样，并减少了血氧分压的常规间接（通过导管）测定。 然而，PaO 2的测量可用于避免选择的PaO 2特异性发病率，例如氧浓度过高引起的早产儿视网膜病。 本文提出的研究将检查高级脉搏血氧仪的使用，以更好地预测动脉PaO 2，允许在离散饱和度范围内维持SpO 2，在低灌注条件下检测真正的低氧血症事件，并在高运动条件下准确测量SpO 2。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulse oximetry has been used in newborn medicine to monitor oxygenation in preterm and term infants for several years. The Principal Investigator and his staff have conducted much of the clinical research validating two of these instruments. Because of the reliability of these instruments they have replaced transcutaneous PaO2 monitors and most blood sampling by direct arterial puncture techniques and have reduced routine indirect (via catheter) determinations of blood oxygen partial pressure. However, measurement of PaO2 serves to avoid selected PaO2 specific morbidities such as retinopathy of prematurity from too high a concentration of oxygen. The research proposed here would examine the use of advanced pulse oximetry to: better predict arterial PaO2, allow maintenance of SpO2 in discrete saturation ranges, detect true hypoxemia events during low perfusion conditions, and accurately measure SpO2 in high motion conditions.