FMRI AND EMOTION IN PERSONALITY DISORDER PATIENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 情感不稳定是边缘型人格障碍(BPD)的核心特征。它可能与严重的功能障碍、高服务利用率和负面的临床结果有关。这种症状可能与情绪刺激的神经处理过程中的潜在障碍有关。在情绪处理的神经生物学方面的研究的最新进展包括在功能磁共振成像中将受试者暴露于情绪刺激。这种类型的范式一直与皮质下和新皮质区域的激活有关，这些区域参与了情绪体验和情绪信息的处理。情感性障碍患者在这些脑区中的几个区域表现出不同的反应，包括杏仁核，以及前扣带回、眶前叶和背外侧前额叶皮质。在这些障碍中，杏仁核和前扣带回皮质之间可能存在着一种特别重要的情绪调节功能关系。相比之下，在BPD中，大脑对情绪刺激的区域激活模式还没有得到很好的研究。这项应用建议使用fmri来启动一项关于大脑对情绪刺激的区域反应的先导性研究，并预测与正常对照组相比，BPD患者杏仁核和扣带皮质区域的激活情况将有所不同。这项研究的结果将被用来检验这种假想的脑功能障碍对于BPD症状(即在诊断类别内)和诊断(即跨诊断类别)的临床特异性，并在情绪不稳定的额叶边缘模型中表征情绪处理障碍的时间和空间动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Affective instability is a core feature of borderline personality disorder (BPD). It may be associated with significant functional impairment, high rates of service utilization, and negative clinical outcomes. This symptom may be related to an underlying disturbance in the neural processing of emotional stimuli. A recent development in the study of neurobilogical aspects of emotion processing involves exposing a subject to emotional stimuli in functional magnetic resonance imaging. This type of paradigm is consistently associated with activation of subcortical and neocortical brain regions known to be involved in emotional experience and processing of emotional information. Patients with affective disorders exhibit altered responses in several of these brain regions, including amygdala, and anterior cingulate, orbitofrontal and dorsolateral prefrontal cortices. A particularly important functional relationship for emotion regulation may exist between the amygdala and anterior cingulate cortex in these disorders in these disorder. In contrast, the pattern of regional brain activation to emotional stimuli has not been well-investigated in BPD. This application proposes to use fMRI to initiate a pilot study of regional brain response to emotional stimuli, with the prediction that BPD patients will show differences in the activation of areas of the amygdala and cingulate cortex compared to normal controls. Results from this study will be utilized to later examine the clinical specificity of this hypothesized brain brain dysfunction for the symptoms (ie within diagnostic category) and for the diagnosis (ie across diagnostic category) of BPD, and to characterize the temporal and spatial dynamics of emotion processing disturbance in a frontolimbic model of affective instability.