Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay

描述（由申请人提供）：我们为FASEB关于“基因表达转录后调控：mRNA衰变机制”的会议申请部分支持，会议将于2006年6月24-29日在CO . Snowmass Village举行。mRNA的周转是基因表达的关键调控因子，但往往未被认识到。mRNA的稳定性决定了其最终的稳态水平。程序性不稳定性是抑制基因表达的一个重要机制，对mRNA质量的监测确保只有“合适”的转录本离开细胞核并被翻译，而RNA干扰依赖于选择性的mRNA转换来实现其生物学后果，而新型药物则针对mRNA的衰变途径。由于这些原因，mRNA的转换引起了生命科学各个领域的高度关注。本次FASEB会议的独特之处在于专注于mRNA的衰变，从而在不同的生物学环境中探索支撑这一普遍过程的细胞和分子水平的机制。这次会议特别值得注意的是，它吸引了研究原核生物和真核生物的研究人员，并关注rna与衰变装置、翻译装置相互作用的机制，以及调节衰变的因素。会议将讨论特定于mRNA 5‘或3’末端的衰变事件及其亚细胞定位；RNA结合蛋白、小RNA和其他衰变因子的结构/功能关系；mRNA衰变与翻译和转录过程的相互作用；RNA质量控制及相关调控网络；以及mRNA衰变的临床和药物相关性。预计会议上的报告将首次公开披露若干关键结构和机制，并为生长、发育和疾病的调控提供新的见解。总之，会议将概述一个令人兴奋的领域的最新进展，并将推动其下一阶段的发展。

DESCRIPTION (provided by applicant): We are requesting partial support for a FASEB Conference on "Post-Transcriptional Regulation of Gene Expression: Mechanisms of mRNA Decay", to be held in Snowmass Village, CO on June 24-29, 2006. Turnover of mRNA is a key, but frequently unrecognized, regulator of gene expression. The stability of an mRNA dictates its ultimate steady-state level. Programmed instability is an important mechanism of repressing gene expression, and the surveillance of mRNA quality ensures that only "fit" transcripts exit the nucleus and are translated, while RNA interference relies on selective mRNA turnover for its biological consequences, whereas novel pharmaceuticals are targeting mRNA decay pathways. For these reasons, mRNA turnover is attracting heightened interest from all areas of the life sciences. The proposed FASEB Conference is unique in concentrating on mRNA decay, thereby exploring in diverse biological settings the mechanisms, both at the cellular and molecular levels that underpin this universal process. The proposed meeting is particularly noteworthy in attracting investigators who study both prokaryotic and eukaryotic organisms, and in focusing on mechanisms by which RNAs interact with the decay apparatus, the translation apparatus, and the factors which modulate decay. The meeting's sessions will address decay events specific for mRNA 5' or 3' termini and their subcellular localization; structure/function relationships in RNA binding proteins, small RNAs, and other decay factors; the interplay of mRNA decay with the processes of translation and transcription; RNA quality control and related regulatory networks; and the clinical and pharmaceutical relevance of mRNA decay. It is anticipated that the presentations at the meeting will include the first public disclosures of several key structures and mechanisms, as well as provide novel insights for the regulation of growth, development, and disease. In short, the conference will provide an overview of the latest progress in an exciting field and will propel the next stage of its development.