Matrix Metalloproteinases Gordon Conference

描述（由申请人提供）：戈登研究会议将选定科学领域的活跃研究人员聚集在一起，目的是通过正式的演讲和广泛的讨论来定义和分析重要问题、最新进展和研究机会。本提案的具体目的是为2005年戈登基质金属蛋白酶（MMPs）研究会议以及2007年和2009年的会议获得部分资金。2005年会议代表了MMP戈登研究会议的第七届两年一次的会议，并将在大天空度假村，大天空，蒙大拿举行。MMPs及其亲属在正常发育和生理以及与组织破坏相关的许多病理条件中发挥核心作用，包括癌症、关节炎、牙周炎、溃疡、动脉粥样硬化、肺纤维化、退行性眼病、感染和炎症。会议将继续提供一个论坛，讨论结构、功能、靶点、抑制剂和分子机制方面的最新进展。我们的目标是创造一种氛围，让有共同兴趣的研究人员相互联系，并让那些拥有更多样化方法的研究人员相互促进。这个。2005年会议将包括八个科学会议：1。金属蛋白酶工具箱：酶和底物的结构生物学降解，可视化MMPs；2. 金属蛋白酶在干细胞发育和衰老中的作用3. 炎症中的金属蛋白酶；4. 金属蛋白酶在神经系统退行性疾病、记忆和衰老中的作用5. 亚当和亚当家族在发育和疾病中的作用6. 金属蛋白酶在癌症中的作用；6. 金属蛋白酶抑制剂tevips等的研究8、金属蛋白酶基因调控、细胞生物学、活化与受体；9. mmp——下一代。会议计划举办两场海报会议，鼓励学生、博士后和青年研究人员与资深研究人员一起介绍他们的工作。我们鼓励所有与会者为海报环节提交摘要，让所有与会者都有机会展示数据并充分参与讨论。传统上，本次会议汇集了不同的国际学术和工业科学家，他们的兴趣范围从基本的分子、细胞和生理机制，到对MMPs作为治疗靶点感兴趣的医生科学家。有限的出席人数，集中的科学会议，以及非常成功的海报会议相结合，为思想交流提供了一个令人兴奋的论坛，并为对MMPs，相关酶及其抑制剂感兴趣的不同群体的科学家提供了广泛的参与机会。因此，我们请求提供资金，部分支持MMPs问题全球协调委员会，以确保在这一关键和极具影响力的会议上提供最相关和最新的信息。

DESCRIPTION (provided by applicant): Gordon Research Conferences bring together active researchers in a selected scientific field with the purpose of defining and analyzing important problems, recent advances and opportunities for research through both formal presentations and extensive discussion. The specific aim of this proposal is to obtain partial funding for the 2005 Gordon Research Conference on Matrix Metalloproteinases (MMPs) and for the conferences in 2007 and 2009. The 2005 Conference represents the 7th biennial meeting of the MMP Gordon Research Conference, and will be held at Big Sky Resort, Big Sky, Montana. MMPs and their relatives play a central role in normal development and physiology and in many pathological conditions associated with tissue destruction, including cancer, arthritis, periodontitis, ulcerations, atherosclerosis, lung fibrosis, degenerative eye diseases, infection and inflammation. The conference will continue to provide a forum for discussion of the latest advances in structure, function, targets, inhibitors and molecular mechanisms. The goal is to create an atmosphere that will weave threads among investigators with common interests, and cross-fertilize those with more diverse approaches. The .2005 conference will consist of eight Scientific Sessions: 1. The Metalloproteinase Toolbox: Structural Biology of Enzymes and Substrates; The Degradome, Visualizing MMPs; 2. Metalloproteinases in Stem Cells, Development and Ageing; 3. Metalloproteinases In Inflammation; 4. Metalloproteinases in The Nervous System-Neurodegenerative Diseases, Memory and Aging; 5. ADAM and ADAMTS Families In Development And Disease; 6. Metalloproteinases in Cancer; 6. Inhibitors Of Metalloproteinases-TEVIPs And Others; 8, Metalloproteinase Gene Regulation, Cell Biology, Activation And Receptors; 9. MMPs-The Next Generation. Two Poster Sessions are planned for the conference to encourage students, postdoctoral fellows and young investigators to join senior investigators in presenting their work. All meeting participants will be encouraged to submit an abstract for the Poster Sessions, allowing all attendees the opportunity to present data and fully participate in discussions. Traditionally, this conference brings together a diverse international group of academic and industrial scientists with interests ranging from basic molecular, cellular and physiological mechanisms MMP action, to physician-scientists interested in MMPs as therapeutic targets. The limited attendance, focused Scientific Sessions, and highly successful Poster Sessions combine to provide an exciting forum for the exchange of ideas and to provide extensive opportunities for participation by a diverse group of scientists interested in MMPs, related enzymes and their inhibitors. Therefore, we are requesting funds to partially support the GRC on MMPs to assure that the most relevant and up-to-date information is featured at this pivotal and highly influential meeting.