ANABOLIC THERAPIES FOR MUSCLE DYSFUNCTION IN WOMEN WITH COPD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：确定1)补充睾丸素或2)力量训练是否能改善重度COPD女性的运动耐量。为患有肺部疾病、支气管炎和肺气肿的妇女设计更好的康复方法。该项目是对患有这些疾病的男性进行的一项类似疗法的研究。将探索两种疗法：1)睾丸激素，众所周知可以增强肌肉；2)腿部肌肉的力量训练(例如举重)。人们正在探索前一种疗法，因为越来越明显的是，尽管女性的睾酮水平比男性低得多，但睾酮是女性肌肉生长的重要中介。已发现患有肺部疾病的女性的睾丸激素水平较低，我们的目的是将其水平提高到健康年轻女性的水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether the exercise tolerance of women with severe COPD will be improved by 1) testosterone supplementation or 2) strength training. To devise better ways to rehabilitate women with lung diseases, bronchitis and emphysema. This project follows on a study of similar therapies in men with these diseases. Two therapies will be explored: 1) testosterone, known to strengthen the muscles, 2) strength training (for example, weight lifting) of the leg muscles. The former therapy is being explored because it is becoming clear that although levels of testosterone are much lower in women than in men, testosterone is an important mediator of muscle growth in women. Testosterone levels have been found to be low in women with lung disease and our intention is to increase levels to those seen in healthy young women.