PERINATAL CORE PROTOCOL FOR HIV INFECTED WOMEN (PACTG P1025, VERSION 20)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然PACTG的主要任务传统上是进行临床试验，但在目前育龄妇女艾滋病毒感染流行的情况下，PACTG招募孕妇参加非干预性、分析性的流行病学研究，以便有条不紊地收集妇女及其婴儿的临床和实验室数据，是适当和必要的。通过这种方式，PACTG可以实现以下重要目标：评价对怀孕期间感染艾滋病毒妇女的管理，确定抗逆转录病毒疗法和其他旨在防止垂直传播和(或)改善产妇健康的干预措施的安全性和有效性。PACTG 367已经证明，可以从在PACTG地点接受护理的妇女及其婴儿中前瞻性地收集数据。此外，这些数据可以在持续的基础上进行分析，以提供不仅用于临床试验设计，而且用于修改临床护理的重要信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although the major mission of the PACTG has traditionally been to conduct clinical trials, at this time in the epidemic of HIV-infection in child-bearing women, it is both appropriate and necessary for the PACTG to recruit pregnant women into a non-interventional, analytic, epidemiologic study in order to methodically collect clinical and laboratory data from the women and their infants. In this way, the PACTG can achieve the important aims of evaluating managment of HIV-infected women during pregnancy and determining the safety and effectiveness of ART and other interventions intended to prevent vertical transmission and/or improve maternal health. PACTG 367 has demonstrated that data can be collected prospectively from women and their infants receiving care at PACTG sites. Furthermore, these data can be analyzed on an ongoing basis to provide important information used not only for the design of clinical trials, but also for modification of clinical care.