FOLIC ACID FOR VASCULAR OUTCOME REDUCTION IN TRANSPLANTATION (FAVORIT)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一种叫做同型半胱氨酸的物质在所有人的血液中循环。与同型半胱氨酸水平正常的人相比，同型半胱氨酸水平升高的人心脏病发作和中风的频率更高。饮食中补充维生素，包括叶酸，可以降低血液中的同型半胱氨酸水平，但目前还不确定同型半胱氨酸水平的降低是否伴随着心脏病发作和中风频率的减少。这项研究的目的是确定通过饮食补充维生素降低同型半胱氨酸水平是否对患者有益。这项研究将在成年肾移植受者中进行，他们将被跟踪五年。因为与普通患者相比，这一人群循环中的同型半胱氨酸水平非常高，心脏病发作和中风的发生率也更高。因此，这项研究被预测是非常安全的，并且很有可能确定降低循环中同型半胱氨酸水平是否是一种合理的临床实践。这项研究将包括接受常规维生素补充剂的对照组和接受相同补充剂以及额外剂量的降低同型半胱氨酸的叶酸和维生素B6和B12的研究组。心脏病发作和中风的频率将在两组之间进行比较，并根据同型半胱氨酸水平进行解释。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A substance called homocysteine circulates in the blood of all people. People with elevated levels of homocysteine experience more frequent heart attacks and strokes compared with people with normal homocystine levels. Dietary supplementation with vitamins, including folic acid, can reduce blood levels of homocystine, but it is uncertain whether this reduction in homocysteine levels is accompanied by a reduction in the frequency of heart attack and stroke. The purpose of this study is to establish whether reducing homocysteine levels with dietary vitamin supplementation is beneficial in patients. This study will be undertaken in adult kidney transplant recipients who will be followed for five years. Because this population has a combination of both very high circulating homocysteine levels and an elevated incidence of heart attack and stroke compared with the general population of patients. Thus this study is predicted to be very safe and to have a high likelihood of establishing whether reduction of circulating homosysteine blood levels is a reasonable clinical practice. The study will include a control group receiving conventional vitamin supplements and a study group receiving the same supplements as well as additional homosysteine-lowering dosages of folic acid and vitamins B6 and B12. The frequency of heart attack and stroke will be compared between the two groups, and interpreted in light of the homocysteine blood levels.