MEAN A1C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项多中心观察性研究的主要目标是根据糖尿病控制和并发症试验(DCCT)和国际临床化学联合会(IFCC)的方法，在1型和2型糖尿病的广泛血糖控制范围内建立平均血糖(MBG)浓度和糖化血红蛋白(HbA1c)值之间的关系。当关系得到确认后，最终目标是实施计算的MBG作为表达HbA1c结果的手段，并使用IFCC-HbA1c来标准化HbA1c分析。 要测试的主要假设是，糖化血红蛋白的标准化测量可以用来准确估计DCCT HbA1c值(4-6.5%，6.6-8.5%和&gt；8.5%)的大范围内前两到三个月的平均血糖浓度，这些受试者属于1型或2型，糖耐量正常，并且具有不同的种族和/或民族背景。第二个目标是从这项研究产生的校准数据中开发预测公式，使HbA1c数据能够在临床实践中以MBG值的形式表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this multi-center observational study is to establish the relationship between Mean Blood Glucose (MBG) concentration and glycohemoglobin (HbA1c) values according to the Diabetes Control and Complications Trial (DCCT) and the International Federation of Clinical Chemistry (IFCC) method over a wide range of glycemic control in both Type 1 and Type 2 Diabetes. The ultimate goal, when the relationship has been confirmed, is to implement the calculated MBG as the means of expressing HbA1c results and use the IFCC-HbA1c to standardize HbA1c assays. The main hypothesis to be tested is that standardized measurements of HbA1c can be used to accurately estimate mean blood glucose concentrations during the preceding two to three months over a wide range of DCCT HbA1c values (4-6.5%, 6.6-8.5% and > 8.5%) in subjects with either Type 1 or Type 2, normal glucose tolerance and of various racial and/or ethnic backgrounds. A secondary aim is to develop predictive formulas from the calibration data that are generated from this study that will allow HbA1c data to be expressed in terms of MBG values in clinical practice.