CARDIOVASCULAR EFFECTS OF AIR POLLUTION IN DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项纵向的前瞻性重复测量小组研究，旨在了解空气污染是否会影响心血管系统，以及它是否会影响糖尿病患者的心血管系统，或者比没有糖尿病的人更有患糖尿病的风险。这项研究还将研究与交通相关的颗粒物污染是否比其他类型的污染对心血管系统的影响更大。这项研究不是随机的，也没有干预。将使用分层混合模型分析空气污染与响应变量之间的关系，以纳入重复措施设计并允许检查效果修改。 在流行病学研究中，人们观察到糖尿病患者对周围空气中颗粒物的影响特别敏感，特别是在心血管后果方面。理解为什么这是真的，可能会为深入了解颗粒毒性的机制提供帮助。要评估这些假设，需要获得糖尿病受试者的稳定人群，这些人群可以被前瞻性地跟踪，并与环境颗粒物污染浓度的详细每日测量结果相匹配。在5次重复访问的75名参与者中(25名糖尿病患者，25名代谢综合征患者，25名非糖尿病患者)，这项研究的主要目的是检验以下假设：1)基础动脉张力(直径)、臂动脉反应性、桡动脉脉搏波、亚临床炎症标志物和心血管风险受到颗粒性空气污染的不利影响。2)与糖尿病患者相比，2型糖尿病患者和处于糖尿病高危状态的代谢综合征患者对这些心血管健康指标中与空气污染相关的变化更为敏感。3)与空气污染有关的主要原因是与交通有关的颗粒物，如碳黑和颗粒物数密度。 在2006年4月1日至2007年3月31日期间，有14名受试者参加了这项研究。 本研究正在积极招募和招收受试者。这项研究没有出现意想不到的安全问题。目前没有初步数据可供分享。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a longitudinal prospective repeated measures panel study looking to see if air pollution affects the cardiovascular system and if it affects the cardiovascular system of people with diabetes or who are at risk for diabetes more than people without diabetes. This study will also look to see if traffic-related particle pollution affects the cardiovascular system more than other kinds of pollution. The study is not randomized and there is no intervention. The relation between air pollution and the response variables will be analyzed using a hierarchical mixed model to incorporate the repeated measures design and allow examination of effect modification. In epidemiological studies, people with diabetes have been observed to be especially sensitive to the effects of ambient airborne particles, especially with regard to cardiovascular outcomes. Understanding why this is true may provide insight into the mechanisms of particle toxicity. To assess these hypotheses requires access to stable population of diabetic subjects that can be followed prospectively and matched to detailed daily measurements of ambient particulate pollution concentrations. In a population of 75 participants (25 with diabetes, 25 with metabolic syndrome, 25 without diabetes) examined at 5 repeated visits, the main aims of the study are to test the following hypothesis: 1) Basal arterial tone (diameter), brachial artery reactivity, radial artery pulse wave, markers of sub-clinical inflammation, and cardiovascular risk are adversely affected by particulate air pollution. 2) Subjects with type 2 diabetes, and subjects with metabolic syndrome placing them at high risk for diabetes are more sensitive to air-pollution related changes in these indicators of cardiovascular health than subjects with diabetes. 3) The association with air pollution is primarily due to traffic related particles, as measured by black carbon and particle number density. Between 4/1/06 and 3/31/07 14 subjects have enrolled in the study. This study is actively recruiting and enrolling subjects. There were no unexpected safety issues in the study. There is no preliminary data to share at this time.