RAPIDITY OF PROGESTERONE SUPPRESION OF LH PULSE FREQUENCY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 黄体生成素在青春期表现出昼夜变化，夜间黄体生成素脉冲频率和幅度增加。我们假设这些促黄体生成素的增加刺激卵巢的P和E_2，从而抑制第二天的促黄体生成素的搏动。为了这一假说的可行性，这些性类固醇必然会有剧烈的作用，影响GnRH脉冲频率在几个小时而不是几天的变化。P抑制GnRH频率的速度尚不清楚。我们建议进一步评估这一点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LH exhibits diurnal changes during puberty, with nocturnal increases in LH pulse frequency and amplitude. We hypothesize that these LH increases stimulate ovarian P and E2, which in turn suppresses LH pulsatility during the following day. For this hypothesis to be viable, these sex steroids would necessarily have acute actions, effecting GnRH pulse frequency changes over hours rather than days. The rapidity with which P supresses GnRH frequency is unknown. We propose to assess this further.