ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项建议将测试的假设，瘦素有助于调节人体内分泌功能的动态。 这一假设将通过三个独立但互补的具体目标进行检验：（1）阐明瘦素在调节人垂体-肾上腺轴中的作用。（2）阐明瘦素在人垂体-性腺轴调节中的作用。（3）阐明瘦素在人垂体-甲状腺轴调节中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal will test the hypothesis that leptin contributes to the regulation of the dynamics of human endocrine function. This hypothesis will be tested by three separate, but complementary, specific aims: (1)Elucidation of the role of leptin in the regulation of the human pituitary-adrenal axis. (2)Elucidation of the role of leptin in the regulation of the human pituitary-gonadal axis. (3)Elucidation of the role of leptin in the regulation of the human pituitary-thyroid axis.