EFFECTS OF LEPTIN REPLACEMENTS IN CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们将评估瘦素缺乏儿童的内分泌和免疫的影响，从一个血缘关系的土耳其家庭。在一项单独的方案（IRB # 01-01-019-03）中，我们研究了该家族的成年成员。我们现在建议研究瘦素替代对由于遗传缺陷而缺乏瘦素的儿童的影响。我们推测，瘦素替代将对免疫和内分泌功能产生显着影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous Turkish family. In a separate protocol (IRB # 01-01-019-03) we have studied adult members of this family. We now propose to study the effects of leptin replacement in children who are deficient in leptin due to a genetic defect. We hypothesize that leptin replacement will have significant effects on immune and endocrine function.