Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.

剖析涉及突触可塑性和社会认知的基因表观遗传调节剂的作用。

基本信息

  • 批准号:
    10614039
  • 负责人:
  • 金额:
    $ 72.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT This proposal represents a highly innovative line of research focused on understanding the mechanism/s by which PHF21B (plant homeodomain finger protein 21B) deficiency impairs social memory. Social impairments, which may be present in multiple psychiatric disorders, are characterized by deficiencies in social functioning. Social cognitive impairments are a central feature of several neurodegenerative, neuropsychiatric, and neurodevelopmental disorders, such as autism spectrum and attention deficit hyperactivity disorder. They also frequently occur following acute brain damage after traumatic brain injury and stroke. We present conceptually novel evidence showing that PHF21B deficiency significantly impairs social memory. In the three-chamber social interaction test, the social preference index of the PHF21B deficient mice did not significantly differ, but they spent more time interacting with the new stranger than with the familiar stranger compared to wild-type mice. Therefore, their social novelty index was significantly greater than wild-type animals, suggesting social memory deficits. Social memory impairments were further confirmed using the 5-trial social memory test. Our new data also support the concept that PHF21B binds to the epigenetic marker tri-methylated Lys36 at histone H3 (H3K36me3), a histone marker associated with expressed gene bodies and recruits proteins implicated in transcription, splicing, and DNA repair. The proposed studies will interrogate the specific role(s) of PHF21B in neuronal function relevant to social behaviors, specifically in social recognition impairment. Expected outcomes are to characterize the role of PHF21B in the hippocampus and identify its target genes and regulatory mechanisms relevant to social memory. We expect that the proposed studies will provide novel insights into the cellular and molecular mechanisms underlying epigenetic changes that affect social recognition memory. The results to be generated by this project have translational potential as they may facilitate the development of novel pharmacological targets for social memory deficits.
项目总结/文摘

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Julio Licinio其他文献

Julio Licinio的其他文献

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{{ truncateString('Julio Licinio', 18)}}的其他基金

Mechanisms of noncanonical caspase 1 signaling in the brain.
大脑中非典型 caspase 1 信号传导机制。
  • 批准号:
    10536643
  • 财政年份:
    2022
  • 资助金额:
    $ 72.29万
  • 项目类别:
Mechanisms of noncanonical caspase 1 signaling in the brain.
大脑中非典型 caspase 1 信号传导机制。
  • 批准号:
    10353135
  • 财政年份:
    2022
  • 资助金额:
    $ 72.29万
  • 项目类别:
Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.
剖析涉及突触可塑性和社会认知的基因表观遗传调节剂的作用。
  • 批准号:
    10446334
  • 财政年份:
    2022
  • 资助金额:
    $ 72.29万
  • 项目类别:
Alternative splicing mechanism in stress.
压力下的选择性剪接机制。
  • 批准号:
    10381608
  • 财政年份:
    2021
  • 资助金额:
    $ 72.29万
  • 项目类别:
Alternative splicing mechanism in stress.
压力下的选择性剪接机制。
  • 批准号:
    10196155
  • 财政年份:
    2021
  • 资助金额:
    $ 72.29万
  • 项目类别:
EFFECTS OF LEPTIN REPLACEMENTS IN CHILDREN
瘦素替代品对儿童的影响
  • 批准号:
    7606773
  • 财政年份:
    2007
  • 资助金额:
    $ 72.29万
  • 项目类别:
ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT
人类瘦素替代品对内分泌的影响
  • 批准号:
    7606741
  • 财政年份:
    2007
  • 资助金额:
    $ 72.29万
  • 项目类别:
DEPRESSION AND METABOLIC SYNDROME IN MEXICAN-AMERICAN WOMEN
墨西哥裔美国女性的抑郁症和代谢综合症
  • 批准号:
    7606774
  • 财政年份:
    2007
  • 资助金额:
    $ 72.29万
  • 项目类别:
DEPRESSION AND METABOLIC SYNDROME IN MEXICAN-AMERICAN WOMEN
墨西哥裔美国女性的抑郁症和代谢综合症
  • 批准号:
    7205446
  • 财政年份:
    2004
  • 资助金额:
    $ 72.29万
  • 项目类别:
CLINICAL PHARMACOGENETICS ANTIPRESSANT RESPONSES IN MEXICAN-AMERICANS
墨西哥裔美国人的临床药物遗传学抗抑郁反应
  • 批准号:
    7205353
  • 财政年份:
    2004
  • 资助金额:
    $ 72.29万
  • 项目类别:

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