ACUTE ESTROGEN IN WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项先导性研究是一项非盲法试验，旨在确定经皮雌激素对绝经后妇女的骨吸收是否有急性影响。具体地说，我们将确定骨吸收标志物(C-端肽、N-端肽和游离脱氧吡啶)的变化，在两周的治疗期间，对雌激素水平低于10pg/ml的65岁以上的绝经后妇女每两周应用一次经皮雌二醇贴片。如果这些妇女的吸收标志物早期显著减少，我们将计划进行一项更大规模的安慰剂对照试验，以额外的时间点来确认和延长这些试点数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is an unblinded trial designed to determine whether there is an acute effect of transdermal estrogen on bone resorption in postmenopausal women. Specifically, we will determine the change in markers of bone resorption (C-telopeptide, N-telopeptide, and free deoxypyridinoline) during two weeks of treatment with a transdermal estradiol patch applied biweekly in postmenopausal women over the age of 65 years with estradiol levels less than 10 pg/ml. If a significant early reduction in resorption markers occurs in these women we will plan a larger placebo-controlled trial with additional time points to confirm and extend these pilot data.