NBP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近，与创伤后应激障碍(PTSD)相关的医学发病率引起了人们的极大兴趣。心血管反应是生理反应性的一个突出特征，而生理反应性是该疾病的核心特征，这增加了对心血管功能产生持久影响的可能性。关于创伤后应激障碍是否与高血压和相关心血管发病率的风险增加有关的研究褒贬不一。与欧洲血统的美国人相比，非裔美国人患高血压及其医疗后果的比例更高。仔细观察相关的临床和流行病学研究表明，包括少数族裔参与者的研究倾向于证明创伤后应激障碍和高血压之间的关系，而一项未能发现这种关系的大型研究的受试者主要是白人。这项拟议的研究旨在调查将创伤后应激障碍与心血管调节联系起来的候选机制，特别是夜间血压调节的作用，以及创伤暴露和夜间血压关系的假设修饰物，包括特质愤怒和偏见和歧视的作用。在随后的研究阶段，我们还将评估肾上腺素能受体的遗传多态与其之间的关系。 健康的志愿者和报告经历过创伤事件和目前认可经历创伤后应激障碍症状的人将被招募参与这项研究。在初步评估期间，所有参与者将完成自我报告措施，评估创伤暴露和创伤后应激障碍相关症状、抑郁、歧视和偏见经历、愤怒管理、负面事件的敏感性、取悦他人的取向、饮食盐摄入量以及个人和病史。在初步评估之后，符合标准的同意参与者将完成临床审查，以进一步评估创伤后应激障碍症状的强度和严重程度、体检和尿毒学筛查、过夜睡眠记录、血压和活动水平的监测，并在研究的后续阶段抽血。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There has been much recent interest in medical morbidity associated with posttraumatic stress disorder(PTSD). Cardiovascular response being a prominent feature of the physiological reactivity that is a core feature of the disorder raises the possibility of enduring effects on cardiovascular function. Studies are mixed as to whether PTSD is associated with an increased risk of hypertension and related cardiovascular morbidity. African Americans have higher rates of hypertension and its medical consequences than Americans of European ancestry. A close look at the relevant clinical and epidemiological research indicates that the studies that include minority participants tend to demonstrate a relationship between PTSD and hypertension and the subjects of a large study that failed to find this relationship were predominantely white. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejudice and discrimination. In a subsequent phase of the research we will also evaluate relationships to genetic polymorphisms of adrenergic receptors. Healthy volunteers and people who report having experinced a traumatic event and current endorse experiencing PTSD symptoms will be recruited to participate in the study. During their initial evaluation, all participants will complete self-report measures which assess for trauma exposure and PTSD related symptoms, depression, experiences of discrimination and prejudice, anger management, sensitivity of negative events, orientation towards pleasing others, dietary salt intake, and personal and medical history. Following initial assessment, consenting participants who meet criteria will complete a clinical review to further assess for intensity and severity of PTSD symptoms, physical exam and urine toxicology screen, overnight sleep recording, monitoring of blood pressure and activity level, and , in a subsequent phase of the research, a blood draws.