Sleep Adaptations to Stress

睡眠对压力的适应

• 批准号: 8536362
• 负责人: THOMAS A MELLMAN
• 金额: $ 17.95万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-24 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8536362
• 关键词: African American; Architecture; Beds; Behavior; Cardiovascular system; Censuses; Characteristics; Cognition; Cohort Studies; Crime; Data; District of Columbia; Environment; Evaluation; Exhibits; Fright; Genotype; Home environment; Impairment; Individual; Laboratories; Life; Life Stress; Life Style; Measures; Mediating; Metabolic Diseases; Modeling; Monitor; Moods; Neighborhoods; Obesity; Participant; Patient Self-Report; Perception; Physiological; Polysomnography; Population Study; Post-Traumatic Stress Disorders; Procedures; Public Health; Quality of life; REM Sleep; Reporting; Research; Risk; Ritual compulsion; Schedule; Sleep; Sleeplessness; Slow-Wave Sleep; Stress; Structure; Time; Trauma; adverse outcome; alertness; functional outcomes; health disparity; insight; mortality; resilience; response; socioeconomics; urban area; vigilance; young adult

DESCRIPTION (provided by applicant): There is substantial evidence that inadequate sleep contributes to health disparities that burden African Americans. Our recent data implicate the fear of losing vigilance to be an important contributor to compromised sleep in the lower socio-economic urban environments in which African Americans are disproportionately represented. Participants with PTSD had reduced slow wave sleep (SWS) and shorter continuous segments of rapid eye movement (REM) sleep. Some of the participants from stressed neighborhoods, however, do not report or exhibit curtailed or disturbed sleep. The purpose of the proposed research is to obtain ecologically valid assessments of the sleep disruptive effects of a stressful neighborhood environment, and determine what contributes resilience versus vulnerability to these effects. We will identify good and poor sleepers living in high crime urban areas. We will incorporate evaluation of the contributions of genotypes previously implicated in sleep tendencies or response to experimental sleep manipulations into models that will also consider life style, trauma exposure, and PTSD. We will monitor pre-sleep behaviors and cognitions and determine how in-home sleep relates to measures obtained in a laboratory setting and contribute to functional outcomes. Insights from this study will inform individual and public healt approaches to ameliorating health disparities attributable to compromised sleep.

描述（由申请人提供）：有大量证据表明，睡眠不足会导致非洲裔美国人的健康差异。我们最近的数据表明，在较低的社会经济城市环境中，害怕失去警惕是导致睡眠妥协的重要贡献者，其中非裔美国人的代表不成比例。具有PTSD的参与者减少了慢波睡眠（SWS）和快速移动（REM）睡眠的连续段。但是，一些来自压力社区的参与者不会报告或表现出限制或干扰的睡眠。拟议的研究的目的是获得对压力大的睡眠破坏性影响的生态有效评估 邻里环境，并确定什么贡献了弹性与对这些影响的脆弱性。我们将确定居住在高犯罪城市地区的良好和贫穷的卧铺。我们将对先前与睡眠趋势或对实验睡眠操作的反应有关的基因型的贡献进行评估，并将其视为生活方式，创伤暴露和PTSD的模型。我们将监控睡眠前的行为和认知，并确定家庭睡眠与实验室环境中获得的措施的关系并促进功能结果。这项研究的洞察力将为您的个人和公共疗法方法提供依据，以改善因睡眠损害而造成的健康差异。