Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS)

乔治敦-霍华德大学临床和转化科学中心（GHUCCTS）是一个主要的 乔治敦大学（GU）和霍华德大学（HU）的合作伙伴关系，与3个附属机构：MedStar 健康研究所（MHRI）、橡树岭国家实验室（ORNL）和华盛顿特区退伍军人协会 事务医疗中心（DCVAMC）。此申请是我们的第二次竞争性更新。的具体目标 GHUCCTS目前：1）继续改善支持高质量，跨学科的基础设施 临床和转化研究，通过GHUCCTS机构之间的机构间合作，以及 作为全国CTSA联盟的多中心临床试验，效率不断提高; 2）进一步建立 GHUCCTS作为机构间合作的典范，利用其多样化的优势和属性， 参与机构，以保持GHUCCTS作为区域CTSA中心， 优势; 3）利用我们的位置，专业知识和少数民族服务机构的共同领导来设计， 实施和传播临床和转化研究，这将对人口产生重大影响， 健康差距，特别是我们社区中服务不足的群体，他们在历史上一直受到 临床研究中的代表，包括来自不同种族、民族和文化背景的人， 残疾人，老年人和退伍军人; 4）继续提供新的充满活力和创新的 为多层次的学员、教职员工提供教育计划，促进团队科学的原则， 为临床和翻译研究者提供高质量的职业发展培训和支持， 5）继续应用和开发创新的分析和计算方法，以加速和 加强翻译。在实现这些具体目标和相应的战略目标时，我们将借鉴 并为国家转化科学推进中心的集体努力和使命做出贡献 （NCATS）和国家CTSA联盟。 在最初的8年作为一个资助的CTSA计划，GHUCCTS发展成为一个功能齐全的多机构中心 这已经改变了GHUCCTS成员机构的CTR， 跨学科合作和指导。在我们的研究中，代表性不足群体的入学率很高 研究，并已增加到两倍以上的国家CTSA中心意味着在我们的培训水平 程序.我们与ORNL合作设计了一个新的核心，利用他们的新技术， 解决哥伦比亚特区健康风险的环境决定因素。我们将继续设计和 完善创新的GHUCCTS计划，以培养未来的临床和转化科学家和领导者， 并在学生、受训人员和医疗保健人员的全方位传播这些教育项目 我们的GHUCCTS机构和国家CTSA网络的专业人员。

The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a primary partnership of Georgetown University (GU) and Howard University (HU), with 3 affiliated institutions: MedStar Health Research Institute (MHRI), Oak Ridge National Laboratory (ORNL), and the Washington DC Veterans Affairs Medical Center (DCVAMC). This application is for our second competitive renewal. The specific aims of GHUCCTS are presently: 1) To continue to improve the infrastructure that supports high quality, interdisciplinary clinical and translational research, both via inter-institutional collaborations among GHUCCTS institutions as well as multicenter clinical trials across the national CTSA consortium, with increasing efficiency; 2) To further establish GHUCCTS as a model of inter-institutional collaboration that leverages the strengths and attributes of its diverse participating institutions in order to maintain GHUCCTS as a regional CTSA hub with unique and synergistic strengths; 3) To leverage our location, expertise and the co-leadership of a minority-serving institution to design, implement and disseminate clinical and translational research that will have a high impact on populations with health disparities, particularly underserved groups in our communities who have been historically under- represented in clinical research studies, including people from diverse racial, ethnic, and cultural backgrounds, people with disabilities, older adults and Veterans; 4) To continue to provide new vibrant and innovative educational programs for multiple levels of trainees, faculty and staff that promote principles of team science, and to provide the high quality career development training and support for the clinical and translational investigators of the future; and 5) To continue to apply and develop innovative analytical and computational methods to speed and enhance translation. In achieving these specific aims and their corresponding strategic goals we will draw from and contribute to the collective efforts and mission of the National Center for Advancing Translational Science (NCATS), and the national CTSA consortium. In the first 8 years as a funded CTSA program, GHUCCTS evolved into a fully functional multi-institutional center that has transformed CTR across each of the GHUCCTS member institutions with growing inter-institutional and inter-disciplinary collaboration and mentorship. Enrollment of under-represented groups is high in our research studies, and have increased to levels that more than double the national CTSA hub mean in our training programs. We have designed a new core in collaboration with ORNL that leverages their novel technologies to address environmental determinants of health risk in the District of Columbia. We will continue designing and refining innovative GHUCCTS programs to train the clinical and translational scientists and leaders of the future, and to disseminate these educational programs across the full spectrum of students, trainees and healthcare professionals at our GHUCCTS institutions and the national CTSA network.