EFFECT OF SODA CONSUMPTION ON URINARY COMPOSITION AND RISK OF STONE FORMATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然增加液体摄入量是尿石症医学治疗的基石，但摄入的特殊液体可能会促进或抑制结石的形成。苏打水的摄入量与尿路结石疾病之间存在正相关关系。这类研究将软饮料归类在一起，尽管一些小型研究表明，可乐会产生负面代谢影响。与用磷酸盐酸化的可乐不同，几种软饮料只用柠檬酸盐酸化，柠檬酸盐在治疗尿路结石疾病方面具有公认的作用。由于柠檬酸盐是一种有效的结石形成抑制剂，一些患有低柠檬酸肾结石的患者可能需要每天补充柠檬酸钾。我们的初步检测显示，1升Fresa(佐治亚州亚特兰大可口可乐)含有3克柠檬酸盐。Fresa有可能为饮食中的柠檬酸盐提供一种廉价、美味和无糖的运输工具。 随着许多患者继续将苏打水作为他们的主要饮料，我们希望找到一种不太可能促进(并潜在地抑制)结石形成的软饮料。因此，我们建议进行一项试验，在正常志愿者的标准饮食中，比较Fresa与水和健怡可乐的代谢影响，以评估苏打水对尿液成分的影响，因为它与结石形成的风险有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although increased fluid intake is a cornerstone of medical management of urolithiasis, the particular fluid ingested may promote or inhibit stone formation. A positive association has been noted between soda consumption and urinary stone disease. Such studies grouped soft drinks together, although some small studies have suggested that the negative metabolic effects occur with cola. Unlike colas which are acidified with phosphates, several soft drinks are acidified only with citrate, which has a well-established role in the treatment of urinary calculus disease. As citrate is a potent inhibitor of calculus formation, some patients with hypocitraturic nephrolithiasis may be treated with a daily supplement of potassium citrate. Our preliminary assays revealed that 1 liter of Fresca (Coca-Cola, Atlanta, GA) contains 3 grams of citrate. Fresca potentially offers an inexpensive, palatable, and sugar-free delivery vehicle for dietary citrate. As many patients continue to imbibe soda as their primary beverage, we hope to identify a soft drink less likely to promote (and potentially inhibit) stone formation. We thus propose a trial to investigate the metabolic effects of Fresca as compared with water and diet cola in normal volunteers on a standardized diet to assess the effect of soda consumption on urinary composition as it relates to the risk of stone formation.