ENDOCRINOPATHIES AFTER HEAD INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 头部损伤导致内分泌疾病的儿童可能在受伤后几年内不会出现症状。还没有关于评估儿童头部损伤后内分泌病的频率的前瞻性试验的报道。 我们假设，损伤后6个月的系统内分泌评估将确定那些有可能发展为后来内分泌疾病的儿童。具体地说，我们假设促甲状腺激素(TSH)或生长激素(GH)分泌模式异常，或血清催乳素浓度升高，将预测其他下丘脑-垂体功能障碍的发展。 在目前的研究中，40名在严重头部损伤中幸存下来的儿童将在受伤时和2至3个月后进行基线甲状腺、皮质醇、生长激素筛查和催乳素测定。然后，他们将在受伤后6个月进行过夜TSH和GH分泌模式的研究。随后，将在受伤后一年评估他们的生长速度和内分泌筛查试验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with endocrinopathies resulting from head injury may not present with symptoms for several years after the injury. No prospective trial has been reported assessing the frequency of endocrinopathy after head injury in children. We hypothesize that systematic endocrine evaluation six months after the injury will identify those children at risk for developing later endocrinopathy. Specifically, we hypothesize that an abnormal pattern of thyrotropin (TSH) or growth hormone (GH) secretion, or an elevated serum prolactin concentration, will predict development of other hypothalamic-pituitary dysfunctions. In the current study, 40 children who have survived significant head injury will have baseline thyroid, cortisol, growth hormone screen, and prolactin measurement at the time of injury and 2 to 3 months later. They will then undergo study of their pattern of overnight TSH and GH secretion at 6 months after injury. Subsequently, their growth rate and endocrine screening tests will be evaluated at one year after injury.