ADOLESCENT GASTRIC BYPASS AND DIABETIC PRECURSORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将开始对病态肥胖成年人和接受减肥手术的青少年的胰岛素抵抗、β细胞功能、人体测量学、营养和体力活动与碳水化合物代谢的关系进行详细研究。虽然众所周知，胃旁路手术会导致纠正某些新陈代谢问题所需的体重减轻，但对于何时需要发生这些变化才能提供最佳的长期结果，我们知之甚少。有证据表明，如果长期不治疗，胰腺可能会“烧坏”，新陈代谢问题可能不会完全逆转。我们将比较胃分流术对成年人和青少年新陈代谢的影响，试图确定与等到成年时进行胃分流术相比，早期行胃分流术是否具有更大的代谢和健康优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will begin a detailed study of insulin resistance, beta cell function, anthropometrics, nutrition, and physical activity in morbidly obese adults compared to adolescents undergoing bariatric surgery in relation to carbohydrate metabolism. While it is known that gastric bypass causes the weight loss necessary to correct some metabolism problems, not much is known about when these changes need to happen to provide the best long term outcome. Evidence suggests that if left untreated for too long the pancreas can "burn out" and then the metabolism problems may be less completely reversed. The effects of gastric bypass on the metabolism of adults and adolescents will be compared to try to determine whether there are greater metabolic and health advantages of performing gastric bypass earlier in life versus waiting until adulthood.